Information Processing Laboratory, School of Information Engineering, Inner Mongolia University of Science and Technology, Baotou, Inner Mongolia, China ; Life Sciences Research Center, School of Life Science and Technology, Xidian University, Xi'an, Shaanxi, China.
PLoS One. 2013 Oct 16;8(10):e77933. doi: 10.1371/journal.pone.0077933. eCollection 2013.
Bidirectional relationship between migraine and depression suggests that there might be some etiological risk factors shared. However, few studies investigated resting state abnormalities affected by depressive symptoms in migraine patients without aura (MWoA).
According to their self-rating depression scale (SDS) score, MWoA were divided into twenty in the SDS (+) (SDS > 49) group and 20 in the SDS (-) (SDS ≤ 49) group. Regional homogeneity (ReHo) method were employed to assess local features of spontaneous brain activity between 1) all MWoA and healthy controls, 2) each subgroup and healthy controls, and 3) SDS (-) group and SDS (+) group.
Compared with healthy controls, decreased ReHo in similar regions were shown in the MWoA group and subgroups. It is noteworthy that the caudate showed increased ReHo in the SDS (-) group compared with healthy controls and the SDS (+) group. Moreover, the average ReHo values of the caudate in SDS (-) group were significantly positively correlated with duration of migraine.
Our results suggested that ReHo patterns in migraine patients may be affected by depressive symptoms and serve as a biomarker to reflect depression severity in MWoA.
偏头痛和抑郁之间存在双向关系，这表明两者可能存在一些共同的病因风险因素。然而，很少有研究调查无先兆偏头痛患者（MWoA）中受抑郁症状影响的静息状态异常。
根据他们的自评抑郁量表（SDS）评分，MWoA 被分为 SDS（+）（SDS > 49）组 20 例和 SDS（-）（SDS ≤ 49）组 20 例。采用局部一致性（ReHo）方法评估 1）所有 MWoA 和健康对照组、2）每个亚组和健康对照组、3）SDS（-）组和 SDS（+）组之间的自发性脑活动的局部特征。
与健康对照组相比，MWoA 组和亚组中相似区域的 ReHo 降低。值得注意的是，SDS（-）组的尾状核显示出比健康对照组和 SDS（+）组更高的 ReHo。此外，SDS（-）组尾状核的平均 ReHo 值与偏头痛持续时间呈显著正相关。
我们的研究结果表明，偏头痛患者的 ReHo 模式可能受到抑郁症状的影响，并可作为反映 MWoA 抑郁严重程度的生物标志物。
