Mental Health Center, First Affiliated Hospital, Guangxi Medical University; Nanning, Guangxi 530021, China.
J Affect Disord. 2011 Dec;135(1-3):326-31. doi: 10.1016/j.jad.2011.06.048. Epub 2011 Jul 23.
Abnormality of limbic-cortical networks was postulated in depression. Using a regional homogeneity (ReHo) approach, we explored the regional homogeneity (ReHo) of the brain regions in patients with first-episode, treatment-naïve, short-illness-duration, and treatment-response depression in resting state to test the abnormality hypothesis of limbic-cortical networks in major depressive disorder (MDD).
Seventeen patients with treatment-response MDD and 17 gender-, age-, and education-matched healthy subjects participated in the resting-state fMRI scans.
Our findings suggested the abnormality of limbic-cortical networks in first-episode, treatment-naïve, short-illness-duration, and treatment-response MDD patients, and added an expanding literature to the abnormality hypothesis of limbic-cortical networks in MDD.
在抑郁症中，假设边缘皮质网络异常。本研究采用局部一致性（ReHo）方法，对首次发作、未经治疗、病程短、治疗反应良好的抑郁症患者静息状态下的脑区局部一致性（ReHo）进行研究，以检验边缘皮质网络在重度抑郁症（MDD）中的异常假说。
17 例治疗反应良好的 MDD 患者和 17 名性别、年龄和教育程度相匹配的健康对照者参与了静息态 fMRI 扫描。
本研究结果提示，首次发作、未经治疗、病程短、治疗反应良好的 MDD 患者边缘皮质网络异常，为 MDD 边缘皮质网络异常假说提供了扩展的文献依据。
