Yu Zhi-Bo, Lv Yan-Bing, Song Ling-Heng, Liu Dai-Hong, Huang Xue-Ling, Hu Xin-Yue, Zuo Zhi-Wei, Wang Yao, Yang Qian, Peng Jing, Zhou Zhen-Hua, Li Hai-Tao
Department of Radiology, The First Affiliated Hospital, Third Military Medical UniversityChongqing, China.
Department of Medical Imaging, PLA No.324 HospitalChongqing, China.
Front Behav Neurosci. 2017 Jun 28;11:124. doi: 10.3389/fnbeh.2017.00124. eCollection 2017.
The objective of this study was to investigate resting-state functional connectivity (FC) differences in insular sub-regions during the interictal phase in patients with migraine without aura (MWoA). Forty-nine MWoA patients (MWoA group) and 48 healthy individuals (healthy control group) were recruited for this study. All of the subjects underwent neurological examination and magnetic resonance imaging (MRI). The MRI data were processed using Brat 1.0 software to obtain a whole-brain FC diagram and using Rest 1.8 software to obtain the FC z-score of the sub-regions of both insulas (six sub-regions on each side). Therefore, there were a total of 12 regions of interest (ROIs) that were used as seed points for the statistical analysis. There was abnormal FC between the insular sub-regions and multiple brain regions in the MWoA patients compared with the healthy control group, and a clear laterality was also observed. In addition, the FC z-score of certain sub-regions was negatively correlated with the disease duration. Different insular sub-regions are functionally associated with different regions of the brain and therefore have different functions. In MWoA, the FC between the insular sub-regions and other brain regions was mostly reduced, while a small amount was increased; additionally, the FC may be ipsilateral with a right-side advantage. Variations in the FC of insular sub-regions can be observed as an important indicator of MWoA.
本研究的目的是调查无先兆偏头痛（MWoA）患者发作间期岛叶亚区域静息态功能连接（FC）的差异。本研究招募了49例MWoA患者（MWoA组）和48名健康个体（健康对照组）。所有受试者均接受了神经学检查和磁共振成像（MRI）。MRI数据使用Brat 1.0软件进行处理以获得全脑FC图，并使用Rest 1.8软件获得双侧岛叶亚区域（每侧六个亚区域）的FC z评分。因此，共有12个感兴趣区域（ROI）用作统计分析的种子点。与健康对照组相比，MWoA患者的岛叶亚区域与多个脑区之间存在异常FC，并且还观察到明显的偏侧性。此外，某些亚区域 的FC z评分与病程呈负相关。不同的岛叶亚区域在功能上与脑的不同区域相关联，因此具有不同的功能。在MWoA中，岛叶亚区域与其他脑区之间的FC大多降低，而少量增加；此外，FC可能以右侧优势为同侧。岛叶亚区域FC的变化可作为MWoA的重要指标。
