中性粒细胞与淋巴细胞比值作为银屑病全身炎症的一种衡量指标。
Neutrophil to lymphocyte ratio as a measure of systemic inflammation in psoriasis.
作者信息
Sen Bilge Bulbul, Rifaioglu Emine Nur, Ekiz Ozlem, Inan Mehmet Ugur, Sen Tugba, Sen Nihat
机构信息
Department of Dermatology and.
出版信息
Cutan Ocul Toxicol. 2014 Sep;33(3):223-7. doi: 10.3109/15569527.2013.834498. Epub 2013 Oct 22.
OBJECTIVE
Psoriasis is a chronic systemic inflammatory disorder. The neutrophil to lymphocyte ratio (N/L ratio) has been used as a marker for systemic inflammatory status. In our study, we aimed to evaluate N/L ratio in patients with psoriasis.
METHODS
This cross-sectional study population consisted of 138 patients with psoriasis and 120 age- and sex-matched control subjects.
RESULTS
The patients had significantly higher neutrophil counts and lower lymphocyte counts than the controls. The N/L ratios and high sensitivity C reactive protein (hs-CRP) levels were also significantly higher in patients. The N/L ratios and hs-CRP levels were increasing with increasing in Psoriasis Area and Severity Index score. Furthermore, the N/L ratios and hs-CRP levels of patients were found to be positively correlated.
CONCLUSIONS
Our data show that the N/L ratio to be a simple, inexpensive and easily assessable marker of systemic inflammation in patients with psoriasis.
目的
银屑病是一种慢性全身性炎症性疾病。中性粒细胞与淋巴细胞比值（N/L比值）已被用作全身炎症状态的标志物。在我们的研究中，我们旨在评估银屑病患者的N/L比值。
方法
这项横断面研究的人群包括138例银屑病患者和120例年龄及性别匹配的对照者。
结果
患者的中性粒细胞计数显著高于对照组，淋巴细胞计数低于对照组。患者的N/L比值和高敏C反应蛋白（hs-CRP）水平也显著更高。N/L比值和hs-CRP水平随着银屑病面积和严重程度指数评分的增加而升高。此外，发现患者的N/L比值与hs-CRP水平呈正相关。
结论
我们的数据表明，N/L比值是银屑病患者全身炎症的一种简单、廉价且易于评估的标志物。
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