Bourgault Serge, Aroichane Maryam, Wittenberg Leah A, Lavallée Andréane, Ma Patrick E
Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, British Columbia V5Z 3N9, Canada.
J Ophthalmic Inflamm Infect. 2013 Oct 22;3(1):61. doi: 10.1186/1869-5760-3-61.
Macular edema is a common complication of uveitis and represents a therapeutic challenge, especially in children. Recently, intravitreal dexamethasone implants have been shown to decrease intraocular inflammation and to control uveitic macular edema in patients with non-infectious intermediate or posterior uveitis.
An 11-year-old boy with bilateral granulomatous idiopathic panuveitis and orbital inflammation experienced macular edema refractory to topical steroids and subcutaneous methotrexate. He was treated with off-label bilateral injections of dexamethasone intravitreal implant. Three months later, his vision had improved from 20/200 in both eyes to 20/30 in the right eye and 20/40 in the left eye. Optical coherence tomography showed complete resolution of the cystoid macular edema and subretinal fluid in both eyes.
This is a rare report of the use of bilateral dexamethasone intravitreal implant in a pediatric patient. The implants achieved complete resolution of the uveitic macular edema with no adverse events 3 months post-implantation.
黄斑水肿是葡萄膜炎的常见并发症，是一项治疗挑战，尤其在儿童患者中。最近，玻璃体内注射地塞米松植入物已被证明可减轻眼内炎症，并控制非感染性中间或后葡萄膜炎患者的葡萄膜炎性黄斑水肿。
一名11岁男孩患有双侧肉芽肿性特发性全葡萄膜炎和眼眶炎症，其黄斑水肿对局部类固醇和皮下注射甲氨蝶呤治疗无效。他接受了未按药品说明书使用的双侧玻璃体内注射地塞米松植入物治疗。三个月后，他的视力从双眼20/200提高到右眼20/30和左眼20/40。光学相干断层扫描显示双眼黄斑囊样水肿和视网膜下液完全消退。
这是一篇关于在儿科患者中使用双侧玻璃体内注射地塞米松植入物的罕见报道。植入物在植入后3个月使葡萄膜炎性黄斑水肿完全消退，且无不良事件发生。
