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儿童葡萄膜炎的管理

Management of pediatric uveitis.

作者信息

Wentworth Bailey A, Freitas-Neto Clovis A, Foster C Stephen

机构信息

Massachusetts Eye Research and Surgery Institution (MERSI) 5 Cambridge Center, Cambridge, MA 02142 USA ; Ocular Immunology and Uveitis Foundation 348 Glen Road, Weston, MA 02493 USA.

Massachusetts Eye Research and Surgery Institution (MERSI) 5 Cambridge Center, Cambridge, MA 02142 USA ; Ocular Immunology and Uveitis Foundation 348 Glen Road, Weston, MA 02493 USA ; Department of Ophthalmology, Harvard Medical School 25 Shattuck Street, Boston, MA 02115 USA.

出版信息

F1000Prime Rep. 2014 Jun 2;6:41. doi: 10.12703/P6-41. eCollection 2014.

Abstract

Pediatric uveitis is a topic of special interest not only because of the unique diagnostic and therapeutic challenges but also because of the lifetime burden of vision loss if the problem is not adequately treated, as well as the economic and psychological toll on the family. Often, uveitis in children is discovered as part of a routine eye exam; this silent, insidious inflammation can be difficult to treat and can lead to further complications if not handled skillfully. Corticosteroids have long been the mainstay of therapy; however, the significant associated side effects mandate a corticosteroid-sparing therapeutic regimen in pursuit of remission. In this review, we cover the therapeutic options for pediatric uveitis, specifically focusing on the most common non-infectious varieties, juvenile idiopathic arthritis-associated uveitis and pars planitis.

摘要

小儿葡萄膜炎是一个特别受关注的话题,这不仅是因为其独特的诊断和治疗挑战,还因为如果问题得不到充分治疗,会导致终身视力丧失负担,以及给家庭带来经济和心理负担。通常,儿童葡萄膜炎是在常规眼科检查中发现的;这种无声、隐匿的炎症可能难以治疗,如果处理不当会导致进一步的并发症。长期以来,皮质类固醇一直是主要治疗药物;然而,其显著的相关副作用要求采用一种尽量减少使用皮质类固醇的治疗方案以实现病情缓解。在本综述中,我们涵盖了小儿葡萄膜炎的治疗选择,特别关注最常见的非感染性类型,即青少年特发性关节炎相关性葡萄膜炎和中间葡萄膜炎。

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