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椎体成形术治疗原发性良性或转移性颈椎病变:长达一年的随访

Vertebroplasty as a Treatment for Primary Benign or Metastatic Cervical Spine Lesions: Up to One Year of Follow-up.

作者信息

Guarnieri G, Vassallo P, Ambrosanio G, Zeccolini F, Lavanga A, Varelli C, Fabozzi G, Izzo R, Muto M

机构信息

Neuroradiology Service, A. Cardarelli Hospital; Naples, Italy -

出版信息

Neuroradiol J. 2010 Mar;23(1):90-4. doi: 10.1177/197140091002300115. Epub 2010 Mar 8.

Abstract

This paper illustrates the validity of vertebroplasty (VP) in patients with primary benign or metastatic lesion in the cervical spine. From January 2006 to December 2007, ten consecutive patients were treated with VP for a total of ten vertebral bodies: two symptomatic vertebral haemangiomas at C5 and C4.3, multiple myeloma at C2 (two cases) and one case at C4, five patients with vertebral metastasis from breast or lung cancer at C2, C4 (three cases) and C5. All the patients complained of pain resistant to continuous medical management. All procedures were performed under general anaesthesia by anterolateral approach under CT or fluoroscopy control with manual dislocation of the carotid axis. A transoral approach under fluoroscopy was performed to treat the C2 lesion. Bone biopsy was never performed. VP was performed to prevent fracture after implantation of a double discal prothesis in two patients. For patients with multiple myeloma, VP was performed to prevent new vertebral fracture. VP was performed before of radiotherapy in three patients with metastasis, and just after radiotherapy in two. Two metastatic patients were lost at one year follow-up due to death from systematic diffusion. Results were evaluated on the Visual Analogue Scale (VAS) and the Oswestry Disability Index (ODS). A successful outcome was observed with a complete resolution or partial reduction of pain in 90% of patients 24-72 hours after VP. At 12 months follow-up, we recorded a reduction of four points in the VAS evaluation and a 45% reduction in the ODS score. No extravertebral vascular or discal cement leakage was observed. At 12 months, X-ray follow-up showed a stable result. Percutaneous treatment with VP for benign or malignant cervical spine lesions is a valuable, mini-invasive and quick method that allows a complete and enduring resolution of painful vertebral symptoms without fracture of the adjacent or distal vertebral bodies.

摘要

本文阐述了椎体成形术(VP)在颈椎原发性良性或转移性病变患者中的有效性。2006年1月至2007年12月,连续10例患者接受了VP治疗,共涉及10个椎体:C5和C4.3处有2例有症状的椎体血管瘤,C2处有2例多发性骨髓瘤,C4处有1例,C2处有5例来自乳腺癌或肺癌的椎体转移瘤,C4处有3例,C5处有1例。所有患者均主诉疼痛,经持续药物治疗无效。所有手术均在全身麻醉下通过前外侧入路,在CT或透视引导下,手动移位颈动脉轴进行。对C2病变采用透视下经口入路治疗。均未进行骨活检。2例患者在植入双节段假体后进行VP以预防骨折。对于多发性骨髓瘤患者,进行VP以预防新的椎体骨折。3例转移瘤患者在放疗前进行VP,2例在放疗后立即进行VP。2例转移瘤患者在1年随访时因全身扩散死亡而失访。结果采用视觉模拟量表(VAS)和奥斯威斯功能障碍指数(ODS)进行评估。VP术后24 - 72小时,90%的患者疼痛完全缓解或部分减轻,观察到治疗成功。在12个月随访时,我们记录到VAS评估降低了4分,ODS评分降低了45%。未观察到椎体外血管或椎间盘骨水泥渗漏。在12个月时,X线随访显示结果稳定。经皮VP治疗颈椎良性或恶性病变是一种有价值、微创且快速的方法,可使疼痛性椎体症状完全且持久缓解,而不会导致相邻或远端椎体骨折。

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