Department of Medical Science, Najafabad Branch, Islamic Azad University, Isfahan, Iran.
J Clin Neurosci. 2013 Dec;20(12):1659-63. doi: 10.1016/j.jocn.2013.04.024. Epub 2013 Oct 19.
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder of upper and lower motor neurons, characterized by progressive muscular atrophy and weakness which culminates in death within 2-5 years. Despite various hypotheses about the responsible mechanisms, the etiology of ALS remains incompletely understood. However, it has been recently postulated that stem cell therapy could potentially target several mechanisms responsible for the etiology of ALS and other nervous system disorders, and could be regarded as one of the most promising therapeutic strategies for ALS treatment. We present a brief review of different methods of stem cell therapy in ALS patients and discuss the results with different cell types and routes of administration.
肌萎缩侧索硬化症（ALS）是一种影响上下运动神经元的神经退行性疾病，其特征是进行性肌肉萎缩和无力，最终导致患者在 2-5 年内死亡。尽管关于其发病机制有多种假说，但 ALS 的病因仍不完全清楚。然而，最近有人提出，干细胞疗法可能针对 ALS 和其他神经系统疾病的发病机制中的多种机制，并且可以被视为 ALS 治疗中最有前途的治疗策略之一。我们简要回顾了 ALS 患者中不同的干细胞治疗方法，并讨论了不同细胞类型和给药途径的结果。
