Shafiee Sahar, Heidarpour Maryam, Sabbagh Sima, Amini Elham, Saffari Hanieh, Dolati Sara, Meamar Rokhsareh
Isfahan Clinical Toxicology Research Center, Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran.
Clinical Development Research Center, Islamic Azad University, Najafabad Branch, Isfahan 81737-35131, Iran.
Asian Biomed (Res Rev News). 2021 Feb 21;15(1):3-18. doi: 10.2478/abm-2021-0002. eCollection 2021 Feb.
Diabetes mellitus is a chronic metabolic disease associated with high cardiovascular risk. A vascular complication of diabetes is foot ulcers. Diabetic foot ulcers are prevalent and substantially reduce the quality of life of patients who have them. Currently, diabetic foot ulcer is a major problem for wound care specialists, and its treatment requires considerable health care resources. So far, various therapeutic modalities have been proposed to treat diabetic foot ulcers and one of them is stem cell-based therapy. Stem cell-based therapy has shown great promise for the treatment of diabetic foot ulcers. This strategy has been shown to be safe and effective in both preclinical and clinical trials. In this review, we provide an overview of the stem cell types and possible beneficial effects of stem cell transplantation therapy for diabetic foot ulcers, and an overview of the current status of stem cell research in both preclinical and clinical trial stages of treatment strategies for diabetic foot ulcers.
糖尿病是一种与高心血管风险相关的慢性代谢性疾病。糖尿病的一种血管并发症是足部溃疡。糖尿病足溃疡很常见，会严重降低患者的生活质量。目前，糖尿病足溃疡是伤口护理专家面临的一个主要问题，其治疗需要大量的医疗资源。到目前为止，已经提出了各种治疗方法来治疗糖尿病足溃疡，其中之一是基于干细胞的疗法。基于干细胞的疗法在治疗糖尿病足溃疡方面显示出了巨大的前景。这一策略在临床前和临床试验中均已证明是安全有效的。在这篇综述中，我们概述了用于糖尿病足溃疡的干细胞类型以及干细胞移植治疗的可能有益效果，以及在糖尿病足溃疡治疗策略的临床前和临床试验阶段干细胞研究的现状。
