Correspondence to Barbara A. Lewis:
J Speech Lang Hear Res. 2013 Oct;56(5):1662-76. doi: 10.1044/1092-4388(2013/12-0119).
In this study, the authors aimed to examine the long-term effects of prenatal cocaine exposure (PCE) on the language development of 12-year-old children using a prospective design, controlling for confounding prenatal drug exposure and environmental factors.
Children who were exposed to cocaine in utero (PCE; n = 183) and children who were not exposed to cocaine (i.e., no cocaine exposure [NCE]; n = 181) were followed prospectively from birth to 12 years of age and were compared on language subtests of the Test of Language Development-Intermediate, Third Edition ( Hammill & Newcomer, 1997b), and phonological processing as measured by the Comprehensive Test of Phonological Processing ( Wagner & Torgesen, 1999). The authors evaluated the relationship of PCE to language development through a multivariate analysis of covariance and regression analyses while controlling for confounders.
Results show that PCE has small effects on specific aspects of language, including syntax and phonological processing. The caregiver variables of lower maternal vocabulary, more psychological symptoms, and a poorer home environment also had consistent effects on language and phonological processing scores.
These findings suggest that PCE continues to have small, subtle effects on specific aspects of language at age 12 years. Phonological processing skills were significantly related to the reading outcomes of letter-word identification, reading fluency, and reading comprehension, indicating that PCE also has small but lasting effects on the language skills that are related to later literacy skills.
本研究旨在采用前瞻性设计,控制混杂的产前药物暴露和环境因素,检验产前可卡因暴露(PCE)对 12 岁儿童语言发展的长期影响。
本研究对 183 名宫内暴露于可卡因的儿童(PCE 组)和 181 名未暴露于可卡因的儿童(即无可卡因暴露 [NCE] 组)进行了前瞻性随访,从出生到 12 岁,并比较了他们在语言发展测试-中级(第三版)(Hammill & Newcomer,1997b)的语言子测试和语音处理上的差异,语音处理通过综合语音处理测试(Wagner & Torgesen,1999)进行测量。作者通过协方差分析和回归分析评估了 PCE 与语言发展的关系,同时控制了混杂因素。
结果表明,PCE 对语言的特定方面(包括语法和语音处理)有较小的影响。照顾者的变量(如母亲词汇量较低、更多的心理症状和较差的家庭环境)也对语言和语音处理分数有一致的影响。
这些发现表明,PCE 对 12 岁儿童语言的特定方面仍有持续的、微小的影响。语音处理技能与字母词识别、阅读流畅性和阅读理解的阅读成绩显著相关,表明 PCE 对与后续读写能力相关的语言技能也有微小但持久的影响。