Nobusawa E, Nakajima K, Nakajima S
Vaccine. 1985 Sep;3(3 Suppl):172-4. doi: 10.1016/0264-410x(85)90098-2.
Antigenic drift of the haemagglutinin (HA) molecule of type A influenza viruses has been thought to occur by the accumulation of a series of point mutations in the antigenically important regions of the molecule. In order to study the antigenic sites on the HA molecule, an attempt was made to use the site-specific mutagenesis method.
甲型流感病毒血凝素（HA）分子的抗原漂移被认为是由该分子抗原性重要区域一系列点突变的积累所致。为了研究HA分子上的抗原位点，人们尝试使用位点特异性诱变方法。
