Kelly Aaron S, Steinberger Julia, Olson Thomas P, Dengel Donald R
Department of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA.
Metabolism. 2007 Jul;56(7):1005-9. doi: 10.1016/j.metabol.2007.03.009.
The aim of the present study was to examine the effect of exercise training on adipokines, inflammatory markers, and oxidative stress in overweight children. Nineteen overweight children were randomly assigned to an aerobic exercise training or sedentary control group for 8 weeks. Measurements included peak oxygen uptake (V o(2)max), body weight and composition, adipokines (C-reactive protein, interleukin 6, tumor necrosis factor alpha, adiponectin, leptin, and resistin), and oxidative stress (8-isoprostane). There were no differences between groups for change in body weight or composition over the 8 weeks. Exercise training improved V o(2)max (exercise group, 1.64 +/- 0.13 to 1.85 +/- 0.17L/min vs control group, 1.83 +/- 0.12 to 1.60 +/- 0.13 L/min, P < .05) but did not change any of the measured adipokines or the marker of systemic oxidative stress, 8-isoprostane. These data suggest that in the absence of weight loss, exercise training alone does not improve the adipokine profile or levels of oxidative stress in overweight children.
本研究的目的是探讨运动训练对超重儿童脂肪因子、炎症标志物和氧化应激的影响。19名超重儿童被随机分为有氧运动训练组或久坐对照组，为期8周。测量指标包括最大摄氧量（V o(2)max）、体重和身体成分、脂肪因子（C反应蛋白、白细胞介素6、肿瘤坏死因子α、脂联素、瘦素和抵抗素）以及氧化应激（8-异前列腺素）。在8周内，两组间体重或身体成分的变化没有差异。运动训练改善了V o(2)max（运动组，从1.64±0.13升至1.85±0.17L/分钟；对照组，从1.83±0.12降至1.60±0.13L/分钟，P<0.05），但并未改变所测量的任何脂肪因子或全身氧化应激标志物8-异前列腺素。这些数据表明，在未减重的情况下，单纯运动训练并不能改善超重儿童的脂肪因子谱或氧化应激水平。
