Sagnella G A, Nolan D A, Shore A C, MacGregor G A
Clin Sci (Lond). 1985 Aug;69(2):223-6. doi: 10.1042/cs0690223.
The effects of synthetic human and rat atrial peptides on sodium and potassium ion transport has been investigated in intact human erythrocytes. The effects of these peptides have been tested on the active, sodium pump-dependent (ouabain-sensitive) and on the sodium-potassium cotransport system (bumetanide-sensitive) with 86Rb used as a tracer. Human (alpha-ANP, 28 amino acids) or rat (atriopeptin III) atrial peptides, over a wide range of concentrations, did not influence the uptake of 86Rb in either the ouabain-sensitive or the bumetanide-sensitive transport system. These results suggest that the natriuretic effect of the atrial peptides is not mediated through inhibition of the sodium pump or the loop-diuretic-sensitive Na-K cotransport.
已在完整的人红细胞中研究了合成的人及大鼠心房肽对钠和钾离子转运的影响。这些肽的作用已通过使用86Rb作为示踪剂，在活性、钠泵依赖性（哇巴因敏感）和钠钾协同转运系统（布美他尼敏感）上进行了测试。人（α-心钠素，28个氨基酸）或大鼠（心房肽III）心房肽在很宽的浓度范围内，对哇巴因敏感或布美他尼敏感的转运系统中86Rb的摄取均无影响。这些结果表明，心房肽的利钠作用不是通过抑制钠泵或对袢利尿剂敏感的钠钾协同转运来介导的。
