Antoniassi Nadia A B, Juffo Gregory D, Santos Adriana S, Pescador Caroline A, Ferreiro Laerte, Driemeier David
1David Driemeier, Departamento de Patologia Clínica Veterinária, Faculdade de Veterinária, Universidade Federal do Rio Grande do Sul, Avenida Bento Gonçalves, no. 9090, 91540-000 Porto Alegre, RS, Brazil.
J Vet Diagn Invest. 2013 Nov;25(6):795-7. doi: 10.1177/1040638713508284. Epub 2013 Oct 23.
Geotrichum spp. are ubiquitous, saprotrophic fungi found in soil, organic matter, and silage, as a contaminant in food products and in the digestive tracts of mammals. The current study reports a case of Geotrichum candidum infection with dermatitis in an aborted bovine fetus with skin and lung lesions. A 6-month-old aborted male Holstein Friesian fetus displayed unusual lesions on the skin of the abdomen, thorax, and head, which was excessively thickened and wrinkled. These changes corresponded to orthokeratotic hyperkeratosis, neutrophil accumulation in the stratum corneum, a pyogranulomatous inflammatory infiltrate, and superficial dermal necrosis. Moderate suppurative multifocal pneumonia was observed. Large numbers of mononuclear cells and occasional fibrin thrombi within blood vessels were found in the lungs, brain, and cerebellum. Gridley staining revealed fungal structures within the skin lesions. The mycological exam demonstrated the growth of G. candidum, and phase contrast microscopy conducted on the abomasal fluid revealed hyphae compatible with this agent. The skin lesions observed, in association with the fungus isolated, indicated that the abortion was due to G. candidum infection of the bovine fetus.
地霉属真菌无处不在，是存在于土壤、有机物和青贮饲料中的腐生真菌，也是食品和哺乳动物消化道中的污染物。本研究报告了一例在流产的患有皮肤和肺部病变的牛胎儿中发生的白地霉感染伴皮炎的病例。一头6个月大流产的雄性荷斯坦弗里生胎儿在腹部、胸部和头部皮肤出现异常病变，皮肤过度增厚且有皱纹。这些变化符合正角化性角化过度、角质层中性粒细胞积聚、脓性肉芽肿性炎症浸润和浅表真皮坏死。观察到中度化脓性多灶性肺炎。在肺、脑和小脑中发现大量单核细胞以及血管内偶尔出现的纤维蛋白血栓。格氏染色显示皮肤病变内有真菌结构。真菌学检查证明有白地霉生长，对皱胃液体进行的相差显微镜检查发现了与该病原体相符的菌丝。观察到的皮肤病变，结合分离出的真菌，表明流产是由于牛胎儿感染了白地霉。
