Department of Environmental Medicine, Institute of Public Health, University of Southern Denmark, Odense, Denmark (JLT-P, HRA, PG, and TKJ); the Research Unit for Dietary Studies, Institute of Preventive Medicine, Copenhagen University Hospitals, Frederiksberg, Denmark (JLT-P and BLH); the National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark (BLH); the Boden Institute of Obesity, Nutrition, Exercise & Eating Disorders, Sydney Medical School, Sydney, Australia (BLH); the Department of Occupational Medicine and Public Health, Tórshavn, Faroe Islands (US); and the Department of Environmental Medicine, Faroese Hospital System, Tórshavn, Faroe Islands (PW).
Am J Clin Nutr. 2014 Jan;99(1):5-13. doi: 10.3945/ajcn.113.066720. Epub 2013 Oct 23.
Chemicals with endocrine-disrupting abilities may act as obesogens and interfere with the body's natural weight-control mechanisms, especially if exposure occurs during prenatal life.
We examined the association between prenatal exposure to polychlorinated biphenyls (PCBs) and p,p'-dichlorodiphenyldichloroethylene (DDE) and subsequent obesity at 5 and 7 y of age.
From 1997 to 2000, 656 pregnant Faroese women were recruited. PCB and DDE were measured in maternal serum and breast milk, and children's weight, height, and waist circumference (WC) were measured at clinical examinations at 5 and 7 y of age. The change in body mass index (BMI) from 5 to 7 y of age was calculated. Analyses were performed by using multiple linear regression models for girls and boys separately, taking into account maternal prepregnancy BMI.
For 7-y-old girls who had overweight mothers, PCB was associated with increased BMI (β = 2.07, P = 0.007), and PCB and DDE were associated with an increased change in BMI from 5 to 7 y of age (PCB: β = 1.23, P = 0.003; DDE: β = 1.11, P = 0.008). No association was observed with BMI in girls with normal-weight mothers. PCB was associated with increased WC in girls with overweight mothers (β = 2.48, P = 0.001) and normal-weight mothers (β = 1.25, P = 0.04); DDE was associated with increased WC only in girls with overweight mothers (β = 2.21, P = 0.002). No associations were observed between PCB or DDE and BMI in 5-y-old girls. For boys, no associations were observed.
Results suggest that prenatal exposure to PCB and DDE may play a role for subsequent obesity development. Girls whose mothers have a high prepregnancy BMI seem most affected.
具有内分泌干扰能力的化学物质可能作为肥胖物，干扰人体自然的体重控制机制，尤其是在胎儿期暴露于此类物质的情况下。
我们研究了母体在产前暴露于多氯联苯（PCBs）和 p,p'-二氯二苯二氯乙烯（DDE）与儿童在 5 岁和 7 岁时发生肥胖的关系。
1997 年至 2000 年，招募了 656 名法罗群岛孕妇。在临床检查中测量了母体血清和母乳中的 PCB 和 DDE，以及儿童在 5 岁和 7 岁时的体重、身高和腰围（WC）。计算了从 5 岁到 7 岁时的体重指数（BMI）变化。对男孩和女孩分别进行了多元线性回归模型分析，同时考虑了母亲孕前 BMI。
对于超重母亲的 7 岁女孩，PCB 与 BMI 增加相关（β=2.07，P=0.007），PCB 和 DDE 与从 5 岁到 7 岁 BMI 的变化相关（PCB：β=1.23，P=0.003；DDE：β=1.11，P=0.008）。对于体重正常的母亲的女孩，没有观察到与 BMI 的关联。PCB 与超重母亲（β=2.48，P=0.001）和体重正常母亲（β=1.25，P=0.04）的女孩的 WC 增加相关；DDE 仅与超重母亲的女孩的 WC 增加相关（β=2.21，P=0.002）。在 5 岁女孩中，没有观察到 PCB 或 DDE 与 BMI 之间的关联。对于男孩，没有观察到关联。
结果表明，产前暴露于 PCB 和 DDE 可能在后续肥胖发展中发挥作用。母亲孕前 BMI 较高的女孩受影响最大。
