Center for Research in Environmental Epidemiology, Barcelona, Spain.
Environ Health Perspect. 2011 Feb;119(2):272-8. doi: 10.1289/ehp.1002169. Epub 2010 Sep 15.
Although it has been hypothesized that fetal exposure to endocrine-disrupting chemicals may increase obesity risk, empirical data are limited, and it is uncertain how early in life any effects may begin.
We explored whether prenatal exposure to several organochlorine compounds (OCs) is associated with rapid growth in the first 6 months of life and body mass index (BMI) later in infancy.
Data come from the INMA (Infancia y Medio-Ambiente) Child and Environment birth cohort in Spain, which recruited 657 women in early pregnancy. Rapid growth during the first 6 months was defined as a change in weight-for-age z-scores > 0.67, and elevated BMI at 14 months, as a z-score ≥ the 85th percentile. Generalized linear models were used to estimate the risk of rapid growth or elevated BMI associated with 2,2-bis(p-chlorophenyl)-1,1-dichloroethylene (DDE), hexachlorobenzene, β-hexachlorohexane, and polychlorinated biphenyls in first-trimester maternal serum.
After multivariable adjustment including other OCs, DDE exposure above the first quartile was associated with doubling of the risk of rapid growth among children of normal-weight (BMI < 25 kg/m2), but not overweight, mothers. DDE was also associated with elevated BMI at 14 months (relative risk per unit increase in log DDE = 1.50; 95% confidence interval, 1.11-2.03). Other OCs were not associated with rapid growth or elevated BMI after adjustment.
In this study we found prenatal DDE exposure to be associated with rapid weight gain in the first 6 months and elevated BMI later in infancy, among infants of normal-weight mothers. More research exploring the potential role of chemical exposures in early-onset obesity is needed.
尽管有假说认为胎儿暴露于内分泌干扰化学物质可能会增加肥胖风险，但实证数据有限，而且尚不确定这些影响最早会在生命中的何时开始。
我们探究了产前接触几种有机氯化合物（OCs）是否与生命最初 6 个月的快速生长以及婴儿后期的体重指数（BMI）有关。
数据来自西班牙的 INMA（Infancia y Medio-Ambiente）儿童与环境出生队列，该队列在妊娠早期招募了 657 名女性。前 6 个月的快速生长定义为体重-年龄 z 分数的变化>0.67，而 14 个月时的 BMI 升高定义为 z 分数≥第 85 个百分位数。使用广义线性模型来估计与第一孕期母体血清中的 2,2-双（对氯苯基）-1,1-二氯乙烯（DDE）、六氯苯、β-六氯环己烷和多氯联苯相关的快速生长或 BMI 升高的风险。
在包括其他 OCs 的多变量调整后，体重正常（BMI<25kg/m2）母亲的儿童中，DDE 暴露量高于第一四分位数与快速生长的风险增加两倍有关，但与超重母亲的儿童无关。DDE 也与 14 个月时的 BMI 升高有关（对数 DDE 每增加一个单位的相对风险=1.50；95%置信区间，1.11-2.03）。其他 OCs 在调整后与快速生长或 BMI 升高无关。
在这项研究中，我们发现产前 DDE 暴露与体重正常母亲的婴儿在前 6 个月的体重快速增长以及婴儿后期的 BMI 升高有关。需要开展更多研究来探索化学暴露在早期肥胖中的潜在作用。
