Centre for Systems Chemistry, Stratingh Institute for Chemistry, University of Groningen, Nijenborgh 4, 9747 AG, Groningen, The Netherlands.
Nat Chem. 2013 Nov;5(11):924-8. doi: 10.1038/nchem.1750. Epub 2013 Sep 15.
Bacterial resistance is a major problem in the modern world, stemming in part from the build-up of antibiotics in the environment. Novel molecular approaches that enable an externally triggered increase in antibiotic activity with high spatiotemporal resolution and auto-inactivation are highly desirable. Here we report a responsive, broad-spectrum, antibacterial agent that can be temporally activated with light, whereupon it auto-inactivates on the scale of hours. The use of such a 'smart' antibiotic might prevent the build-up of active antimicrobial material in the environment. Reversible optical control over active drug concentration enables us to obtain pharmacodynamic information. Precisely localized control of activity is achieved, allowing the growth of bacteria to be confined to defined patterns, which has potential for the development of treatments that avoid interference with the endogenous microbial population in other parts of the organism.
细菌耐药性是现代社会面临的一个重大问题，部分原因在于抗生素在环境中的积累。因此，人们迫切需要开发新型的分子方法，以实现具有高时空分辨率和自动失活功能的外部触发抗生素活性增加。在这里，我们报告了一种响应性广谱抗菌剂，它可以通过光进行时间控制，随后在数小时内自动失活。使用这种“智能”抗生素可以防止环境中活性抗菌物质的积累。对活性药物浓度的可逆光学控制使我们能够获得药效学信息。通过精确的局部活性控制，可以将细菌的生长限制在特定的模式内，这有望开发出避免干扰生物体其他部位内源性微生物群的治疗方法。
