Bioulac-Sage P, Saric J, Boussarie L, Balabaud C
Hepatology. 1985 Nov-Dec;5(6):1183-9. doi: 10.1002/hep.1840050620.
In five rats with congenital portacaval shunt, liver atrophy, hyperplastic foci in the periportal zone, atrophic hepatocytes in the centrolobular zone, well-preserved hepatocyte ultrastructure with abundant rough endoplasmic reticulum, packed mitochondria and numerous peroxisomes were observed as in surgical portacaval shunt. However, portal triads were abnormal in contrast to surgical shunt. In large portal triads, hepatic arteries were prominent, bile ducts numerous and portal veins were lacking. Instead, small or large capillaries were seen in the portal tracts usually at the periphery. These capillaries appeared to be in continuity with nearby sinusoids presenting the ultrastructural characteristics of capillaries. These observations suggest that absence of the portal vein is compensated by formation of neocapillaries. It is assumed that these capillaries originate from periportal sinusoids and are necessary to distribute blood to all sinusoids and form a reservoir to lower arterial pressure.
在5只患有先天性门腔分流的大鼠中，观察到肝脏萎缩，门周区有增生灶，中央小叶区有萎缩的肝细胞，肝细胞超微结构保存良好，有丰富的粗面内质网、密集的线粒体和大量过氧化物酶体，这与外科门腔分流的情况相同。然而，与外科分流相比，门三联体是异常的。在大的门三联体中，肝动脉突出，胆管众多，门静脉缺失。相反，在门管区通常是外周可见大小不等的毛细血管。这些毛细血管似乎与附近的血窦相连，呈现出毛细血管的超微结构特征。这些观察结果表明，门静脉的缺失通过新毛细血管的形成得到了补偿。据推测，这些毛细血管起源于门周血窦，对于将血液分布到所有血窦并形成一个降低动脉压的储血库是必要的。
