Vonnahme F J, Dubuisson L, Kubale R, Klempnauer R, Grün M
Br J Exp Pathol. 1984 Oct;65(5):585-96.
A congenital portacaval shunt was discovered in five rats. In these animals the hepatic artery was the only blood vessel perfusing the liver; the portal vein was absent. The livers were small and mainly hypoplastic, but light microscopy revealed the occurrence of focal hyperplastic alterations and occasional hyperplastic nodules. TEM and SEM showed these areas to be composed of clustered hepatocytes, separated by widened intercellular spaces. The cell membranes carried numerous pleomorphic microvilli, and the cytoplasma contained densely packed mitochondria, some of which were giant sized. Liver cells in the centrilobular region were hypoplastic. Comparison with findings of experimental portacaval anastomosis suggest that in congenital-shunt animals, the overall hypoplasia of the liver with the formation of hyperplastic areas is a consequence of the lack of portal blood.
在五只大鼠中发现了先天性门腔分流。在这些动物中，肝动脉是灌注肝脏的唯一血管；门静脉缺失。肝脏体积小，主要发育不全，但光学显微镜检查显示出现了局灶性增生性改变和偶尔的增生性结节。透射电子显微镜和扫描电子显微镜显示这些区域由聚集的肝细胞组成，细胞间隙增宽。细胞膜上有许多形态各异的微绒毛，细胞质中含有密集排列的线粒体，其中一些是巨大型的。小叶中央区的肝细胞发育不全。与实验性门腔吻合术的结果比较表明，在先天性分流动物中，肝脏整体发育不全并形成增生区域是门静脉血缺乏的结果。
