Department of Plastic Surgery, Stoke Mandeville Hospital, Aylesbury, Bucks, UK.
BMJ Open. 2013 Oct 22;3(10):e003709. doi: 10.1136/bmjopen-2013-003709.
There is growing interest in the potential use of autologous fat grafting (AFG) for the purposes of breast reconstruction. However, concerns have been raised regarding the technique's clinical effectiveness, safety and interference with screening mammography. The objective of this systematic review was to determine the oncological, clinical, aesthetic and functional, patient reported, process and radiological outcomes for AFG.
All original studies, including randomised controlled trials, cohorts studies, case-control studies, case series and case reports involving women undergoing breast reconstruction. All AFG techniques performed for the purposes of reconstruction in the postmastectomy or breast conserving surgery setting will be considered. Outcomes are defined within this protocol along; oncological, clinical, aesthetic and functional, patient reported, process and radiological domains. The search strategy has been devised to find papers about 'fat grafting and breast reconstruction' and is outlined within the body of this protocol. The full search strategy is outlined within the body of the protocol. The following electronic databases will be searched from 1 January 1986 to 6 June 2013: PubMed, MEDLINE, EMBASE, SCOPUS, CINAHL, PsycINFO, SciELO, The Cochrane Library, including the Cochrane Database of Systematic Reviews (CDSR), Cochrane Central Register of Controlled Trials (CENTRAL), Database of Abstracts of Reviews of Effect (DARE), the Cochrane Methodology Register, Health Technology Assessment Database, the NHS Economic Evaluation Databases and Cochrane Groups, ClinicalTrials.gov, Current Controlled Trials Database, the World Health Organisation (WHO) International Clinical Trials Registry Platform, UpToDate.com, NHS Evidence and the York Centre for Reviews and Dissemination. Grey literature searches will also be conducted as detailed in our review protocol. Eligibility assessment occurred in two stages, title and abstract screening and then full text assessment. Data were extracted and stored in a database with standardised extraction fields to facilitate easy and consistent data entry.
This systematic review will be published in a peer-reviewed journal. It will also be presented at national and international conferences in the fields of plastic, reconstructive and aesthetic surgery and at more general surgical and methodological conferences. It will be disseminated electronically and in print. Brief reports of the review findings will be disseminated directly to the appropriate audiences of surgeons and societies through email and other modes of communication. Updates of the review will be conducted to inform and guide healthcare practice and policy.
PROSPERO-National Institute of Health Research (NIHR) Prospective Register of Systematic Reviews (CRD42013005254).
自体脂肪移植（AFG）在乳房重建中的潜在应用越来越受到关注。然而，人们对该技术的临床效果、安全性以及对乳房筛查 X 光检查的干扰表示担忧。本系统评价的目的是确定 AFG 的肿瘤学、临床、美容和功能、患者报告、过程和影像学结果。
所有原始研究，包括随机对照试验、队列研究、病例对照研究、病例系列和涉及接受乳房重建的女性的病例报告，都将被考虑在内。所有为乳房切除术后或保乳手术后重建目的而进行的 AFG 技术都将被考虑在内。本方案中定义了以下定义的结果：肿瘤学、临床、美容和功能、患者报告、过程和影像学领域。搜索策略旨在寻找有关“脂肪移植和乳房重建”的论文，并在本方案正文中概述。完整的搜索策略在方案正文中概述。将从 1986 年 1 月 1 日至 2013 年 6 月 6 日搜索以下电子数据库：PubMed、MEDLINE、EMBASE、SCOPUS、CINAHL、PsycINFO、SciELO、The Cochrane Library，包括 Cochrane 系统评价数据库（CDSR）、Cochrane 对照试验中心注册（CENTRAL）、疗效评价文摘数据库（DARE）、Cochrane 方法学登记册、卫生技术评估数据库、NHS 经济评估数据库和 Cochrane 组、ClinicalTrials.gov、当前对照试验数据库、世界卫生组织（WHO）国际临床试验注册平台、UpToDate.com、NHS 证据和约克评论和传播中心。还将按照我们的审查方案进行灰色文献搜索。资格评估分两个阶段进行，标题和摘要筛选，然后是全文评估。数据被提取并存储在一个数据库中，该数据库具有标准化的提取字段，便于轻松和一致地输入数据。
本系统评价将发表在同行评议的期刊上。它还将在塑料、重建和美容外科领域的国家和国际会议以及更广泛的外科和方法学会议上进行介绍。它将通过电子和印刷方式传播。将通过电子邮件和其他通信方式直接向外科医生和学会的相关受众分发审查结果的简要报告。将进行审查更新，以告知和指导医疗保健实践和政策。
PROSPERO-国家卫生研究院（NIHR）前瞻性系统评价注册（CRD42013005254）。
