不同冻融胚胎移植周期中解冻后培养期的结局。
The outcome of different post-thawed culture period in frozen-thawed embryo transfer cycle.
机构信息
Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Baiyundadaobei Road, Baiyun District, Guangzhou, 510515, China.
出版信息
J Assist Reprod Genet. 2013 Dec;30(12):1589-94. doi: 10.1007/s10815-013-0120-0. Epub 2013 Oct 25.
Abstract
PURPOSE
To study the influence of post-thawed culture (2-4 h and 20-24 h) on the outcome of frozen-thawed embryo transfer (FET) cycle.
METHODS
In this retrospective study, a total of 1,353 patients were undergoing the FET treatment at the reproductive medical center between June 2010 and July 2012. 3,398 frozen-thawed embryos were divided in two study groups, depending on their post-thawed culture period: short culture (2-4 h) group and long culture (20-24 h) group. Groups were compared including clinical pregnancy rate, implantation rate, spontaneous abortion rate, ectopic pregnancy rate, multiple pregnancy rate, live birth rate and birth weight.
RESULTS
When embryos including at least one grade I embryo after thawed transferred, the clinical pregnancy rate, implantation rate, multiple pregnancy rate, abortion rate, ectopic pregnancy rate, live birth rate and birth weight were similar in the short culture group compared with these in the long culture group.
CONCLUSIONS
The outcomes of the two approaches (short culture and long culture) are no different in FET cycles.
摘要
目的
研究解冻后培养（2-4 小时和 20-24 小时）对冷冻胚胎解冻移植（FET）周期结局的影响。
方法
本回顾性研究共纳入 2010 年 6 月至 2012 年 7 月在生殖医学中心接受 FET 治疗的 1353 例患者。将 3398 枚冷冻解冻胚胎分为两组，根据解冻后的培养时间分为短培养（2-4 小时）组和长培养（20-24 小时）组。比较两组的临床妊娠率、着床率、自然流产率、宫外孕率、多胎妊娠率、活产率和出生体重。
结果
当解冻后移植至少有一枚 I 级胚胎时，短培养组的临床妊娠率、着床率、多胎妊娠率、流产率、宫外孕率、活产率和出生体重与长培养组相似。
结论
FET 周期中两种方法（短培养和长培养）的结局无差异。
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