Haywood Lillian M B, Sheahan Breanna J
Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27607, USA.
Vet Sci. 2024 Oct 7;11(10):480. doi: 10.3390/vetsci11100480.
Equine colitis is a devastating disease with a high mortality rate. Infectious pathogens associated with colitis in the adult horse include , , spp., /, and equine coronavirus. Antimicrobial-associated colitis can be associated with the presence of infectious pathogens. Colitis can also be due to non-infectious causes, including non-steroidal anti-inflammatory drug administration, sand ingestion, and infiltrative bowel disease. Current treatments focus on symptomatic treatment (restoring fluid and electrolyte balance, preventing laminitis and sepsis). Intestinal epithelial ion channels are key regulators of electrolyte (especially sodium and chloride) and water movement into the lumen. Dysfunctional ion channels play a key role in the development of diarrhea. Infectious pathogens, including spp. and , have been shown to regulate ion channels in a variety of ways. In other species, there has been an increased interest in ion channel manipulation as an anti-diarrheal treatment. While targeting ion channels also represents a promising way to manage diarrhea associated with equine colitis, ion channels have not been well studied in the equine colon. This review provides an overview of what is known about colonic ion channels and their known or putative role in specific types of equine colitis due to various pathogens.
马结肠炎是一种死亡率很高的毁灭性疾病。与成年马结肠炎相关的传染性病原体包括 、 、 属、 / 以及马冠状病毒。与抗菌药物相关的结肠炎可能与传染性病原体的存在有关。结肠炎也可能由非传染性原因引起，包括使用非甾体抗炎药、摄入沙子和浸润性肠病。目前的治疗重点是对症治疗（恢复液体和电解质平衡、预防蹄叶炎和败血症）。肠上皮离子通道是电解质（尤其是钠和氯）和水分进入肠腔的关键调节因子。功能失调的离子通道在腹泻的发生中起关键作用。包括 属和 在内的传染性病原体已被证明以多种方式调节离子通道。在其他物种中，作为一种抗腹泻治疗方法，对离子通道操纵的兴趣日益增加。虽然靶向离子通道也是治疗马结肠炎相关腹泻的一种有前景的方法，但离子通道在马结肠中尚未得到充分研究。本综述概述了关于结肠离子通道的已知信息以及它们在由各种病原体引起的特定类型马结肠炎中的已知或假定作用。
