Bellhorn R W, Korte G E, Abrutyn D
Department of Surgery, School of Veterinary Medicine, University of California, Davis 95616.
Lab Anim Sci. 1988 Feb;38(1):46-50.
Superficial punctate opacities were observed in the palpebral aperture region of the cornea of Sprague-Dawley and Wistar rats of both sexes and varying ages, but they were not observed in Lewis rats. Slit-lamp biomicroscopy localized the opacities in the subepithelial corneal stroma. Electron microscopy demonstrated 0.1-2.0 micron granules at the stromal-epithelial interface and in the adjacent stroma. Smaller granules, consisting of aggregates of amorphous granular material, were associated with bundles of filaments among collagen fibers. Larger granules were located adjacent to and sometimes straddle the epithelial basement membrane. The overlying epithelial cells were displaced, but otherwise appeared normal. Large granules consisted of layered dark and light electron dense rings and appeared in some instances to represent fusing of smaller granules. This rat keratopathy bears certain resemblance to granular dystrophy of man (Groenouw's Type I), but histochemically is dissimilar.
在不同年龄的雌雄斯普拉格-道利大鼠和Wistar大鼠角膜睑裂区观察到浅表点状混浊，但在刘易斯大鼠中未观察到。裂隙灯生物显微镜检查将混浊定位在角膜上皮下基质中。电子显微镜显示在基质-上皮界面和相邻基质中有0.1-2.0微米的颗粒。较小的颗粒由无定形颗粒物质聚集体组成，与胶原纤维束中的细丝束相关。较大的颗粒位于上皮基底膜附近，有时横跨上皮基底膜。上方的上皮细胞移位，但其他方面看起来正常。大颗粒由明暗相间的电子致密环层组成，在某些情况下似乎代表较小颗粒的融合。这种大鼠角膜病与人的颗粒状营养不良（格罗诺夫I型）有一定相似之处，但组织化学上不同。
