1. Department of Haematology, Navy General Hospital, Fucheng Road, Beijing, PR China.
Int J Biol Sci. 2013 Sep 14;9(9):887-94. doi: 10.7150/ijbs.7220. eCollection 2013.
It is well known that most of the ionizing radiation-induced damage is caused by hydroxyl radicals (·OH) follows radiolysis of H2O. Molecular hydrogen (H2) has antioxidant activities by selectively reducing ·OH and peroxynitrite(ONOO-). We firstly hypothesized and demonstrated the radioprotective effect of H2 in vitro and in vivo, which was also repeated on different experimental animal models by different departments. A randomized, placebo-controlled study showed that consumption of hydrogen-rich water reduces the biological reaction to radiation-induced oxidative stress without compromising anti-tumor effects. These encouraging results suggested that H2 represents a potentially novel preventative strategy for radiation-induced oxidative injuries. H2 is explosive. Therefore, administration of hydrogen-rich solution (physiological saline/pure water/other solutions saturated with H2) may be more practical in daily life and more suitable for daily consumption. This review focuses on major scientific and clinical advances of hydrogen-rich solution/H2 as a new class of radioprotective agent.
众所周知，大多数电离辐射引起的损伤是由 H2O 辐射分解产生的羟基自由基（·OH）引起的。氢气（H2）通过选择性还原·OH 和过氧亚硝酸盐（ONOO-）具有抗氧化活性。我们首先假设并证明了 H2 在体外和体内的辐射防护作用，不同部门的不同实验动物模型也重复了这一作用。一项随机、安慰剂对照研究表明，富氢水的摄入可降低辐射诱导的氧化应激的生物学反应，而不影响抗肿瘤作用。这些令人鼓舞的结果表明，H2 代表了一种潜在的新型辐射诱导氧化损伤预防策略。H2 是爆炸性的。因此，富含氢气的溶液（生理盐水/纯水/其他饱和氢气的溶液）的给药在日常生活中可能更实用，更适合日常消费。本综述重点介绍了富氢溶液/H2 作为一种新型辐射防护剂的主要科学和临床进展。
