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阿尔茨海默病患者的巨细胞病毒特异性 CD8 T 细胞比例降低，但无一般免疫衰老迹象。

Decreased proportion of cytomegalovirus specific CD8 T-cells but no signs of general immunosenescence in Alzheimer's disease.

机构信息

Department of Medical Sciences, Uppsala University, Uppsala, Sweden ; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.

出版信息

PLoS One. 2013 Oct 14;8(10):e77921. doi: 10.1371/journal.pone.0077921. eCollection 2013.

DOI:10.1371/journal.pone.0077921
PMID:24155977
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3796487/
Abstract

Cytomegalovirus (CMV) has been suggested as a contributing force behind the impaired immune responsiveness in the elderly, with decreased numbers of naïve T-cells and an increased proportion of effector T-cells. Immunological impairment is also implicated as a part of the pathogenesis in Alzheimer's disease (AD). The aim of this study was to investigate whether AD patients present with a different CMV-specific CD8 immune profile compared to non-demented controls. Blood samples from 50 AD patients and 50 age-matched controls were analysed for HLA-type, CMV serostatus and systemic inflammatory biomarkers. Using multi-colour flow cytometry, lymphocytes from peripheral blood mononuclear cells were analysed for CMV-specific CD8 immunity with MHC-I tetramers A01, A02, A24, B07, B08 and B35 and further classified using CD27, CD28, CD45RA and CCR7 antibodies. Among CMV seropositive subjects, patients with AD had significantly lower proportions of CMV-specific CD8 T-cells compared to controls, 1.16 % vs. 4.13 % (p=0.0057). Regardless of dementia status, CMV seropositive subjects presented with a lower proportion of naïve CD8 cells and a higher proportion of effector CD8 cells compared to seronegative subjects. Interestingly, patients with AD showed a decreased proportion of CMV-specific CD8 cells but no difference in general CD8 differentiation.

摘要

巨细胞病毒 (CMV) 被认为是导致老年人免疫应答受损的原因之一，其特征是幼稚 T 细胞数量减少，效应 T 细胞比例增加。免疫功能障碍也被认为是阿尔茨海默病 (AD) 发病机制的一部分。本研究旨在探讨 AD 患者与非痴呆对照组相比是否存在不同的 CMV 特异性 CD8 免疫特征。对 50 名 AD 患者和 50 名年龄匹配的对照组的血液样本进行 HLA 型、CMV 血清状态和系统性炎症生物标志物分析。使用多色流式细胞术，用 MHC-I 四聚体 A01、A02、A24、B07、B08 和 B35 分析外周血单个核细胞中 CMV 特异性 CD8 免疫，并用 CD27、CD28、CD45RA 和 CCR7 抗体进一步分类。在 CMV 血清阳性的受试者中，AD 患者 CMV 特异性 CD8 T 细胞的比例明显低于对照组，分别为 1.16%和 4.13%（p=0.0057）。无论痴呆状态如何，CMV 血清阳性的受试者与血清阴性的受试者相比，幼稚 CD8 细胞的比例较低，效应 CD8 细胞的比例较高。有趣的是，AD 患者 CMV 特异性 CD8 细胞的比例降低，但一般 CD8 分化无差异。

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