N-卤代邻苯二甲酰亚胺作为氮源和卤素源的简单烯烃的催化分子间卤代酰胺化反应。
Catalytic intermolecular haloamidation of simple alkenes with N-halophthalimide as both nitrogen and halogen source.
机构信息
Beijing National Laboratory for Molecule Sciences (BNLMS), CAS Key Laboratory for Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences , Beijing 100190, China.
出版信息
Org Lett. 2013 Nov 15;15(22):5702-5. doi: 10.1021/ol402726d. Epub 2013 Oct 24.
PMID:24156477
Abstract
A simple, efficient, and highly atom economic haloamidation of simple alkenes has been developed, using AgBF4 or InBr3/AgBF4 (1:3) as catalyst and N-halophthalimide as both nitrogen and halogen source. A broad range of olefins can be applied to afford vicinal haloamines in good yields and with high regioselectivity and diastereoselectivity.
摘要
发展了一种简单、高效、高原子经济性的简单烯烃的偕卤酰胺化反应，使用 AgBF4 或 InBr3/AgBF4（1:3）作为催化剂，N-卤代邻苯二甲酰亚胺作为氮源和卤素源。该反应具有广泛的底物适用性，可以高区域选择性和立体选择性地得到偕二卤代胺，产率良好。
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