Department of Laser Medicine, Chinese People's Liberation Army General Hospital, Beijing 100853, China.
Exp Biol Med (Maywood). 2013 Dec;238(12):1344-9. doi: 10.1177/1535370213505958. Epub 2013 Oct 24.
To raise photosensitizer concentration level during the photodynamic therapy process, two new methods of photosensitizer administration were investigated. The first method involves the slow intravenous injection of photosensitizer throughout the first 15 min of irradiation, and the second method involves 30 min fomentation before photosensitizer injection and irradiation. The fluorescence spectra of port wine stain skin were monitored and the therapeutic effect correlated index was calculated with a previously published spectral algorithm. Thirty cases were divided into group A (slow injection of photosensitizer during the first 15 min), group B (fomentation), and group C (control group, traditional injection method), with 10 cases in each group. To analyze the effect of these two new methods, the change of therapeutic effect correlated index values of two photodynamic therapy sessions for each patient were calculated, and the photodynamic therapy outcome was compared. The results showed that the change of therapeutic effect correlated index in group A was slightly more remarkable than that in the control group. The change of therapeutic effect correlated index in group B was similar to that in the control group. Slow injection of photosensitizer during photodynamic therapy has a potential to increase photosensitizer concentration level during photodynamic therapy. However, fomentation before photodynamic therapy has no such potential. There is a need for new methods to be attempted.
为了在光动力疗法过程中提高光敏剂浓度水平，研究了两种新的光敏剂给药方法。第一种方法是在照射的前 15 分钟内缓慢静脉注射光敏剂，第二种方法是在注射和照射前进行 30 分钟的热敷。监测葡萄酒色斑皮肤的荧光光谱，并使用先前发表的光谱算法计算治疗效果相关指数。将 30 例患者分为 A 组（在最初 15 分钟内缓慢注射光敏剂）、B 组（热敷）和 C 组（对照组，传统注射方法），每组 10 例。为了分析这两种新方法的效果，计算了每位患者两次光动力治疗过程中治疗效果相关指数值的变化，并比较了光动力治疗的结果。结果表明，A 组治疗效果相关指数的变化略高于对照组。B 组治疗效果相关指数的变化与对照组相似。光动力疗法期间缓慢注射光敏剂有增加光动力疗法期间光敏剂浓度水平的潜力。然而，光动力疗法前的热敷没有这种潜力。需要尝试新的方法。
