Cogniaux J, Jacquemin P C
Leuk Res. 1985;9(9):1117-26. doi: 10.1016/0145-2126(85)90101-8.
The proteins of HTLV-I virus, the only human retrovirus implicated in the etiopathogenesis of the T-cell leukemia, were previously studied with the use of monoclonal antibodies. Different groups have produced specific monoclonal antibodies that recognized the core proteins of the virus p19 and p24 and in one case a monoclonal specific of a gp21 protein. All these antibodies were shown to react with the virus-producing fixed cells. We also developed a battery of antibodies against p24 and p19 antigens from HTLV-I virus but the anti-p19 monoclonal antibodies happened to recognize epitopes exposed on the surface of live HTLV-I infected cells. One of the monoclonal antibody that bound to the surface of HTLV infected cells recognized a protein of an approximate mol. wt of 33 kilodalton (KD). These antibodies that bound to the live cells should be precious tools to study leukemic patients with T-cell leukemia and the evolution of the live cell populations during the course of the disease.
人类嗜T淋巴细胞病毒I型（HTLV-I）是唯一一种与T细胞白血病发病机制相关的人类逆转录病毒，其蛋白质此前已通过单克隆抗体进行研究。不同的研究小组制备了识别该病毒核心蛋白p19和p24的特异性单克隆抗体，还有一个小组制备了针对gp21蛋白的特异性单克隆抗体。所有这些抗体都被证明能与产生病毒的固定细胞发生反应。我们还研制了一系列针对HTLV-I病毒p24和p19抗原的抗体，但抗p19单克隆抗体恰好识别活的HTLV-I感染细胞表面暴露的表位。其中一种与HTLV感染细胞表面结合的单克隆抗体识别一种分子量约为33千道尔顿（KD）的蛋白质。这些与活细胞结合的抗体应该是研究T细胞白血病患者以及疾病过程中活细胞群体演变的宝贵工具。
