抗人T细胞白血病-淋巴瘤病毒（HTLV）p24内部核心蛋白的单克隆抗体。用作诊断探针及HTLV的细胞定位。
Monoclonal antibodies against human T cell leukemia-lymphoma virus (HTLV) p24 internal core protein. Use as diagnostic probes and cellular localization of HTLV.
作者信息
Palker T J, Scearce R M, Miller S E, Popovic M, Bolognesi D P, Gallo R C, Haynes B F
出版信息
J Exp Med. 1984 Apr 1;159(4):1117-31. doi: 10.1084/jem.159.4.1117.
Abstract
Four monoclonal antibodies, human T cell leukemia-lymphoma virus (HTLV) 6, 7, 8, and 9, which react with the 24,000 dalton internal core protein of HTLVI, have been developed. These monoclonal antibodies reacted with only HTLV-infected cells and not with a broad spectrum of normal, neoplastic, mitogen-stimulated, or virus-infected cells and tissues. HTLV 6, 7, 8, and 9 identified at least two different antigenic determinants on HTLV p24 that were also recognized by antibodies present in HTLV+ patient sera. Monoclonal antibodies HTLV 6, 7, 8, and 9 reacted in indirect immunofluorescence assays with HTLV p24 localized at the cell surface of 5-d cultures of HTLV-infected T cells and, as well, reacted with T cells infected with HTLVII, a new type of HTLV isolated from a patient (MO) with a T cell variant of hairy cell leukemia. Thus, HTLV 6, 7, 8, and 9 should prove to be useful diagnostic reagents in the identification of HTLV- and HTLVII-infected T cells.
摘要
已研制出四种单克隆抗体，即人类T细胞白血病-淋巴瘤病毒（HTLV）6、7、8和9，它们可与HTLVI的24000道尔顿内部核心蛋白发生反应。这些单克隆抗体仅与感染HTLV的细胞发生反应，而不与多种正常、肿瘤、有丝分裂原刺激的或病毒感染的细胞及组织发生反应。HTLV 6、7、8和9识别出HTLV p24上至少两种不同的抗原决定簇，这些抗原决定簇也能被HTLV阳性患者血清中的抗体识别。单克隆抗体HTLV 6、7、8和9在间接免疫荧光试验中，可与位于感染HTLV的T细胞5天培养物细胞表面的HTLV p24发生反应，并且也可与感染HTLVII的T细胞发生反应，HTLVII是从一名患有毛细胞白血病T细胞变异型的患者（MO）中分离出的一种新型HTLV。因此，HTLV 6、7、8和9应被证明是鉴定感染HTLV和HTLVII的T细胞的有用诊断试剂。
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