Department of Preventive Medicine, Stony Brook Medicine, Stony Brook, New York.
Invest Ophthalmol Vis Sci. 2013 Dec 3;54(13):7871-84. doi: 10.1167/iovs.13-12403.
To use the Gompertz function to estimate the age and the amount of myopia at stabilization and to evaluate associated factors in the Correction of Myopia Evaluation Trial (COMET) cohort, a large ethnically diverse group of myopic children.
The COMET enrolled 469 ethnically diverse children aged 6 to younger than 12 years with spherical equivalent refraction between -1.25 and -4.50 diopters (D). Noncycloplegic refraction was measured semiannually for 4 years and annually thereafter. Right eye data were fit to individual Gompertz functions in participants with at least 6 years of follow-up and at least seven refraction measurements over 11 years. Function parameters were estimated using a nonlinear least squares procedure. Associated factors were evaluated using linear regression.
In total, 426 participants (91%) had valid Gompertz curve fits. The mean (SD) age at myopia stabilization was 15.61 (4.17) years, and the mean (SD) amount of myopia at stabilization was -4.87 (2.01) D. Ethnicity (P < 0.0001) but not sex or the number of myopic parents was associated with the age at stabilization. Ethnicity (P = 0.02) and the number of myopic parents (P = 0.01) but not sex were associated with myopia magnitude at stabilization. At stabilization, African Americans were youngest (mean age, 13.82 years) and had the least myopia (mean, -4.36 D). Participants with two versus no myopic parents had approximately 1.00 D more myopia at stabilization. The age and the amount of myopia at stabilization were correlated (r = -0.60, P < 0.0001).
The Gompertz function provides estimates of the age and the amount of myopia at stabilization in an ethnically diverse cohort. These findings should provide guidance on the time course of myopia and on decisions regarding the type and timing of interventions.
利用戈珀特函数估计近视稳定时的年龄和近视程度，并评估大型多民族近视儿童近视评估试验（COMET）队列中的相关因素。
COMET 纳入了 469 名年龄在 6 岁以下至 12 岁之间、等效球镜屈光度在-1.25 至-4.50 屈光度（D）之间的不同种族的儿童。非睫状肌麻痹验光每半年测量一次，共 4 年，此后每年测量一次。在至少有 6 年随访且在 11 年内至少有 7 次屈光度测量的参与者中，右眼数据拟合到个体戈珀特函数中。使用非线性最小二乘法程序估计函数参数。使用线性回归评估相关因素。
共有 426 名（91%）参与者的戈珀特曲线拟合有效。近视稳定时的平均（标准差）年龄为 15.61（4.17）岁，稳定时的平均（标准差）近视程度为-4.87（2.01）D。种族（P<0.0001），但不是性别或近视父母的数量与稳定时的年龄有关。种族（P=0.02）和近视父母的数量（P=0.01），但不是性别与稳定时的近视程度有关。在稳定时，非裔美国人最年轻（平均年龄 13.82 岁），近视程度最低（平均-4.36 D）。有两个而非没有近视父母的参与者稳定时近视程度约增加 1.00 D。稳定时的年龄和近视程度呈负相关（r=-0.60，P<0.0001）。
戈珀特函数为多民族队列提供了稳定时年龄和近视程度的估计。这些发现应该为近视的时间进程以及干预类型和时间的决策提供指导。
