Metabolism Unit, Center for Endocrinology, Metabolism, and Diabetes, Department of Medicine, and Molecular Nutrition Unit, Center for Biosciences NOVUM, Karolinska Institute at Karolinska University Hospital Huddinge, S-14186 Stockholm, Sweden.
Cell Metab. 2012 Dec 5;16(6):693-705. doi: 10.1016/j.cmet.2012.11.001.
The circulating FGFs are a new group of proteins believed to function as classic hormones. With emphasis on human metabolism, we critically review current data, and propose that--although a number of questions remain--circulating FGF23 is pivotal in the control of phosphate and vitamin D metabolism, and may have additional systemic effects, particularly in chronic kidney disease; that FGF19 signaling is important for the regulation of bile acid metabolism, whereas its physiological role in promoting glucose and lipid metabolism is less well understood; and that the physiological role of circulating FGF21 in metabolic homeostasis warrants further investigation.
循环 FGF 是一类新的蛋白质，被认为具有经典激素的功能。本文着重于人类代谢，我们批判性地回顾了当前的数据，并提出尽管仍有许多问题有待解决，但循环 FGF23 在控制磷酸盐和维生素 D 代谢方面起着关键作用，并且可能具有额外的全身作用，特别是在慢性肾脏病中；FGF19 信号对于胆汁酸代谢的调节很重要，而其在促进葡萄糖和脂质代谢方面的生理作用尚不清楚；循环 FGF21 在代谢平衡中的生理作用值得进一步研究。
