Department of Medicinal Chemistry, CSIR-Central Institute of Medicinal and Aromatic Plants (CIMAP), P.O. CIMAP, Kukrail Picnic Spot Road, Lucknow 226 015, India.
Curr Med Chem. 2014;21(4):458-500. doi: 10.2174/09298673113206660291.
Malaria is one of the deadliest diseases on the planet affecting about 50% of the population worldwide. It is a leading cause of morbidity and mortality in the developing world. Plasmodium falciparum, a tiny parasite is the major cause of malaria and is possibly the most dangerous stow-away in history. Malaria has become a major economic concern to some of the tropical and sub-tropical countries. Though a number of antimalarials have been developed from plants as such or their semi-synthetic analogues, there is again an alarming situation of drug resistance against most of the antimalarial drugs. Plants have been an excellent source of antimalarial compounds. There are several plant leads exhibiting antimalarial activity better than the existing drugs. A systematic evaluation of these plant based leads is the need of the time to develop safe, effective and affordable new antimalarials. The present review is an update of plant based antimalarial agents.
疟疾是地球上最致命的疾病之一，影响着全球约 50%的人口。它是发展中国家发病率和死亡率的主要原因。疟原虫是一种微小的寄生虫，是疟疾的主要病因，可能是历史上最危险的偷渡者。疟疾已成为一些热带和亚热带国家的主要经济关注点。尽管已经从植物或其半合成类似物中开发出了许多抗疟药物，但大多数抗疟药物再次出现了令人震惊的耐药情况。植物一直是抗疟化合物的极好来源。有几种植物先导化合物表现出比现有药物更好的抗疟活性。对这些基于植物的先导化合物进行系统评估是开发安全、有效和负担得起的新型抗疟药物的当务之急。本综述是对基于植物的抗疟药物的最新更新。
