Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX 75390.
J Cell Biol. 2013 Oct 28;203(2):171-3. doi: 10.1083/jcb.201309130.
The vesicular adenosine triphosphatase (ATPase) acidifies intracellular compartments, including synaptic vesicles and secretory granules. A controversy about a second function of this ATPase in exocytosis has been fuelled by questions about multiple putative roles of acidification in the exocytic process. Now, Poëa-Guyon et al. (2013. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201303104) present new evidence that the vesicular ATPase performs separate acidification and exocytosis roles and propose a mechanism for how these two functions are causally linked.
囊泡腺苷三磷酸酶（ATP 酶）使包括突触小泡和分泌颗粒在内的细胞内隔室酸化。囊泡 ATP 酶在胞吐作用中除了具有酸化这一主要功能外，还有其他一些假定作用，这一争议一直存在。近期，Poëa-Guyon 等人（2013. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201303104）提出了新的证据，表明囊泡 ATP 酶具有独立的酸化和胞吐作用功能，并提出了这两种功能如何因果关联的机制。
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