肽核酸对微小RNA成熟的抑制作用。
Inhibition of miRNA maturation by peptide nucleic acids.
作者信息
Avitabile Concetta, Fabbri Enrica, Bianchi Nicoletta, Gambari Roberto, Romanelli Alessandra
机构信息
Dipartimento delle Scienze Biologiche, Università di Napoli "Federico II", Napoli, Italy.
出版信息
Methods Mol Biol. 2014;1095:157-64. doi: 10.1007/978-1-62703-703-7_13.
PMID:24166311
Abstract
Molecules able to interfere in miRNA genesis and function are potent tools to unravel maturation and processing pathways. Antisense oligonucleotides or analogs are actually employed for the inhibition of miRNA function. Here we illustrate how Peptide Nucleic Acids oligomers targeting pre-miRNA are exploited to inhibit miRNA maturation.
摘要
能够干扰微小RNA（miRNA）生成和功能的分子是揭示其成熟和加工途径的有力工具。反义寡核苷酸或类似物实际上被用于抑制miRNA的功能。在此，我们阐述了靶向前体miRNA的肽核酸寡聚物是如何被用于抑制miRNA成熟的。
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