Falcicchio Pierpaolo, Wolterink-Van Loo Suzanne, Franssen Maurice C R, van der Oost John
Laboratory of Microbiology, Wageningen University, Dreijenplein 10, 6703HB, Wageningen, The Netherlands,
Extremophiles. 2014 Jan;18(1):1-13. doi: 10.1007/s00792-013-0593-x. Epub 2013 Oct 29.
Generating new carbon-carbon (C-C) bonds in an enantioselective way is one of the big challenges in organic synthesis. Aldolases are a natural tool for stereoselective C-C bond formation in a green and sustainable way. This review will focus on thermophilic aldolases in general and on dihydroxyacetone phosphate-dependent aldolases in particular. Biochemical properties and applications for synthesis of rare sugars and carbohydrates will be discussed.
以对映选择性方式生成新的碳-碳（C-C）键是有机合成中的重大挑战之一。醛缩酶是一种以绿色可持续方式进行立体选择性C-C键形成的天然工具。本综述将总体聚焦于嗜热醛缩酶，尤其关注磷酸二羟丙酮依赖性醛缩酶。将讨论其生化特性以及在稀有糖和碳水化合物合成中的应用。
