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长期持续的疾病以及随着时间推移不饮酒,对将终生戒酒者用作对照组的影响。

Persistent long-standing illness and non-drinking over time, implications for the use of lifetime abstainers as a control group.

作者信息

Ng Fat Linda, Cable Noriko, Marmot M G, Shelton Nicola

机构信息

Department of Epidemiology and Public Health, UCL, , London, UK.

出版信息

J Epidemiol Community Health. 2014 Jan;68(1):71-7. doi: 10.1136/jech-2013-202576. Epub 2013 Oct 28.

DOI:10.1136/jech-2013-202576
PMID:24166583
Abstract

BACKGROUND

Non-drinkers are shown to have worse health than moderate drinkers in later life. We examine the preceding health status of non-drinkers in early adulthood, and secondly whether persistent poor health is associated with persistent non-drinking.

METHODS

Using two prospective British birth cohort studies established in 1958 (National Child Development Study (NCDS)) and in 1970 (British Cohort Study (BCS)), participants who reported 'never' or 'never had an alcoholic drink' to drinking status questions in successive waves from 23 to 26 years in the NCDS/BCS were derived as 'lifetime abstainers'. Logistic regression on the odds of being a lifetime abstainer was carried out on changes in limiting long-standing illness (LLSI) in the NCDS and long-standing illness (LSI) in the BCS, adjusting for sex, education, poor psychosocial health, marital and parental status.

RESULTS

Participants with an LLSI in consecutive waves since 23 years had 4.50 times the odds of someone who did not have an LLSI of being a lifetime abstainer at 33 years (95% CI 1.99 to 10.18) and 7.02 times the odds at 42 years (2.39 to 20.66) after adjusting for all factors. Similarly, in the BCS, having an LSI in consecutive waves resulted in higher odds of being a lifetime abstainer at 30 years (OR 2.80, 1.88 to 4.18) and 34 years (OR 3.33, 2.01 to 5.53).

CONCLUSIONS

Persistent LSI was associated with remaining a non-drinker across adulthood. Studies comparing the health outcomes of moderate drinkers to lifetime abstainers that do not account for pre-existing poor health may overestimate the better health outcomes from moderate alcohol consumption.

摘要

背景

研究表明,在晚年,不饮酒者的健康状况比适度饮酒者更差。我们研究了成年早期不饮酒者之前的健康状况,其次,长期健康状况不佳是否与持续不饮酒有关。

方法

利用1958年建立的两项英国前瞻性出生队列研究(全国儿童发展研究(NCDS))和1970年建立的(英国队列研究(BCS)),在NCDS/BCS中,从23岁到26岁连续几轮报告饮酒状况问题为“从不”或“从未喝过酒”的参与者被确定为“终身戒酒者”。对NCDS中限制长期疾病(LLSI)和BCS中长期疾病(LSI)的变化进行逻辑回归,以分析成为终身戒酒者的几率,并对性别、教育程度、心理社会健康状况差、婚姻和父母状况进行调整。

结果

自23岁起连续几轮患有LLSI的参与者在33岁时成为终身戒酒者的几率是没有LLSI者的4.50倍(95%CI 1.99至10.18),在42岁时是7.02倍(2.39至20.66),所有因素调整后。同样,在BCS中,连续几轮患有LSI导致在30岁时成为终身戒酒者的几率更高(OR 2.80,1.88至4.18),在34岁时为(OR 3.33,2.01至5.53)。

结论

长期LSI与成年期持续不饮酒有关。比较适度饮酒者与终身戒酒者健康结果的研究,如果不考虑先前存在的健康状况不佳,可能会高估适度饮酒带来的更好健康结果。

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