通过光激活铂类抗癌配合物产生单线态氧和氨配体。
De novo generation of singlet oxygen and ammine ligands by photoactivation of a platinum anticancer complex.
机构信息
Department of Chemistry, University of Warwick, Coventry CV4 7AL (United Kingdom); Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190 (P.R. China).
出版信息
Angew Chem Int Ed Engl. 2013 Dec 16;52(51):13633-7. doi: 10.1002/anie.201307505. Epub 2013 Oct 25.
Worth the excitement: Highly reactive oxygen and nitrogen species are generated by photoactivation of the anticancer platinum(IV) complex trans,trans,trans-[Pt(N3 )2 (OH)2 (MA)(Py)] (MA=methylamine, Py=pyridine). Singlet oxygen is formed from the hydroxido ligands and not from dissolved oxygen, and ammine ligands are products from the conversion of azido ligands to nitrenes. Both processes can induce oxidation of guanine.
值得兴奋的是
通过光激活抗癌铂（IV）配合物顺式，顺式，顺式-[Pt（N3）2（OH）2（MA）（Py）]（MA=甲胺，Py=吡啶）可以生成高反应性的氧和氮物种。单线态氧是由羟基亚基形成的，而不是由溶解氧形成的，氨基亚基是由叠氮化物向氮烯转化的产物。这两个过程都可以诱导鸟嘌呤氧化。
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