Stores G
Dev Med Child Neurol. 1975 Oct;17(5):647-58. doi: 10.1111/j.1469-8749.1975.tb03536.x.
There is increasing evidence that various types of behavioural disturbance, other than those described for phenytoin, for example, may occur from the use of anti-epileptic medication, and it has been suggested that these disturbances may not always be reversible. There are suspicions also that certain groups of patients--especially those with structural brain damage--are particularly susceptible. These and other factors relevant to the study of the effects of anti-epileptic drugs on behaviour are comprehensively reviewed. It is concluded that the psycho-pharmacology of anti-epileptic drugs is unsatisfactory at present because of inadequate and unsophisticated reporting of behavioural change and because of the common problem of polypharmacy, and that more accurate observations are needed on less heterogeneous groups of patients that have been described in the past.
越来越多的证据表明，使用抗癫痫药物可能会引发除苯妥英所描述的那些之外的各种行为障碍，并且有人提出这些障碍可能并非总是可逆的。也有人怀疑某些患者群体——尤其是那些有脑结构损伤的患者——特别容易受到影响。本文全面综述了与抗癫痫药物对行为影响研究相关的这些及其他因素。得出的结论是，目前抗癫痫药物的精神药理学并不令人满意，原因在于行为变化的报告不充分且不够精细，以及多药合用这一常见问题，并且需要对过去所描述的异质性较小的患者群体进行更准确的观察。
