Department of Ophthalmology, Changhua Christian Hospital, , Changhua, Taiwan.
Br J Ophthalmol. 2014 Jan;98(1):110-4. doi: 10.1136/bjophthalmol-2013-303945. Epub 2013 Oct 29.
To investigate whether patients with central serous chorioretinopathy (CSCR) have increased risk of coronary heart disease (CHD).
Population-based retrospective cohort and case control study. Longitudinal data from the Taiwan National Health Insurance Research Database (2000-2009) were analysed. The study cohort comprised 835 patients with a diagnosis of CSCR and 4175 age and gender matched patients without CSCR. Kaplan-Meier plots and log-rank tests were used to compare differences in the hazard rates of CHD between the CSCR and non-CSCR cohorts. Stratified Cox proportional hazard models were applied to examine the association between CSCR and CHD, adjusting for potential confounding factors.
The 5-year CHD cumulative incidence for patients with CSCR was nearly twofold that of the non-CSCR cohort (6.12% vs 3.29%, p=0.004) from the log-rank test. The adjusted CHD HR of CSCR versus non-CSCR was 1.61 (95% CI 1.12 to 2.30, p=0.009) from the Cox model. Specifically, the HR for male patients was 1.72 (95% CI 1.14 to 2.59, p=0.010) and for female patients it was 1.34 (95% CI 0.64 to 2.84, p=0.438).
Male patients with CSCR had a significantly higher CHD rate than those without CSCR, indicating that CSCR may be a potential risk factor for the development of CHD for men.
探讨中心性浆液性脉络膜视网膜病变（CSCR）患者发生冠心病（CHD）的风险是否增加。
这是一项基于人群的回顾性队列和病例对照研究。对来自台湾全民健康保险研究数据库（2000-2009 年）的纵向数据进行分析。研究队列包括 835 例 CSCR 患者和 4175 例年龄和性别相匹配的非 CSCR 患者。采用 Kaplan-Meier 图和对数秩检验比较 CSCR 组和非 CSCR 组 CHD 危险率的差异。应用分层 Cox 比例风险模型，调整潜在混杂因素，检验 CSCR 与 CHD 之间的关联。
CSCR 患者的 5 年 CHD 累积发病率几乎是非 CSCR 队列的两倍（6.12%对 3.29%，p=0.004，对数秩检验）。Cox 模型调整后的 CSCR 与非 CSCR 相比 CHD 的 HR 为 1.61（95%CI 1.12 至 2.30，p=0.009）。具体而言，男性患者的 HR 为 1.72（95%CI 1.14 至 2.59，p=0.007），女性患者为 1.34（95%CI 0.64 至 2.84，p=0.438）。
CSCR 男性患者的 CHD 发生率明显高于非 CSCR 患者，表明 CSCR 可能是男性发生 CHD 的潜在危险因素。
