Department of Ophthalmology, National Yang-Ming University Hospital, Yilan, Taiwan.
Br J Ophthalmol. 2012 Dec;96(12):1484-8. doi: 10.1136/bjophthalmol-2012-301810. Epub 2012 Sep 13.
Central serous chorioretinopathy (CSCR) is a common maculopathy that features choroidal circulatory disturbance. This population-based cohort study aimed to explore the relationship between CSCR and the future development of ischaemic stroke.
Data were obtained from Taiwan's national health insurance research database. From 2000 to 2007, 1814 patients with newly diagnosed CSCR were eligible for inclusion in the study cohort. Using stratified random sampling, 9648 enrollees matched with the study subjects in terms of sex, age, monthly income, geographical location and time of enrolment were selected as the control group. Stroke-free survival analysis was assessed using a Kaplan-Meier method. Cox proportional hazard regressions were performed to calculate the HR of ischaemic stroke for the two groups after adjusting for possible confounding variables.
Of the sampled patients, 45 (2.5%) from the CSCR cohort and 157 (1.6%) from the control group developed ischaemic stroke during a mean follow-up period of 3.9 ± 2.2 years. CSCR patients had a significantly higher incidence of ischaemic stroke than those without a diagnosis of CSCR (p=0.003). After adjusting for age, sex and chronic comorbidities at baseline, CSCR patients were found to have a 1.56-fold (95% CI 1.11 to 2.18, p=0.010) greater risk of a subsequent ischaemic stroke than the matched controls.
CSCR is an independent indicator for the increased risk of subsequent ischaemic stroke development.
中心性浆液性脉络膜视网膜病变（CSCR）是一种常见的黄斑病变，其特征为脉络膜循环障碍。本基于人群的队列研究旨在探讨 CSCR 与未来缺血性卒中发展之间的关系。
数据来自台湾全民健康保险研究数据库。2000 年至 2007 年期间，1814 例新诊断 CSCR 患者符合纳入研究队列标准。采用分层随机抽样法，选取 9648 名与研究对象在性别、年龄、月收入、地理位置和入组时间上相匹配的参保者作为对照组。采用 Kaplan-Meier 方法评估无卒中生存情况。采用 Cox 比例风险回归计算两组在调整可能的混杂变量后缺血性卒中的 HR。
在抽样患者中，CSCR 队列中有 45 例（2.5%）和对照组中有 157 例（1.6%）在平均 3.9±2.2 年的随访期间发生缺血性卒中。CSCR 患者的缺血性卒中发生率明显高于未诊断 CSCR 的患者（p=0.003）。在调整基线时的年龄、性别和慢性合并症后，CSCR 患者发生后续缺血性卒中的风险是匹配对照组的 1.56 倍（95%CI 1.11 至 2.18，p=0.010）。
CSCR 是后续缺血性卒中发展风险增加的独立指标。
