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聚多卡醇硬化治疗骨巨细胞瘤。

Sclerotherapy with polidocanol for treatment of aneurysmal bone cysts.

机构信息

Orthopaedics Section, Department of Molecular Medicine and Surgery , Karolinska Institute and Department of Orthopaedics, Karolinska University Hospital, Stockholm , Sweden.

出版信息

Acta Orthop. 2013 Oct;84(5):502-5. doi: 10.3109/17453674.2013.850013. Epub 2013 Oct 31.

DOI:10.3109/17453674.2013.850013
PMID:24171682
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3822137/
Abstract

BACKGROUND AND PURPOSE

Recent data suggest that percutaneous sclerotherapy is a safe alternative to surgery for treatment of aneurysmal bone cysts (ABCs). We present our experience of this method.

METHODS

We retrospectively analyzed data from 38 consecutive patients treated with repeated injections of polidocanol. Each injection consisted of 2-4 mg polidocanol per kg body weight. Radiological and clinical assessments were performed until healing.

RESULTS

All cycts except 1 healed after a median of 4 (1-11) injections. A lesion failed to heal in 1 patient, who was operated. 3 patients experienced minor local inflammatory reactions.

INTERPRETATION

Our results show that percutaneus sclerotherapy with polidocanol has high efficacy in the treatment of ABCs, with a low frequency of side effects. Our findings corroborate data presented in previous publications. We believe that the method will be especially valuable in ABCs of the pelvis and sacrum, where surgery is associated with considerable morbidity.

摘要

背景与目的

最近的数据表明,对于骨囊肿(ABC)的治疗,经皮硬化疗法是一种安全的手术替代方法。我们介绍了这种方法的经验。

方法

我们回顾性分析了 38 例连续接受聚多卡醇重复注射治疗的患者数据。每次注射的剂量为每公斤体重 2-4 毫克聚多卡醇。进行影像学和临床评估,直到愈合。

结果

除 1 例外,所有囊肿在中位数为 4(1-11)次注射后愈合。1 例患者病变未愈合,行手术治疗。3 例患者出现轻微局部炎症反应。

解释

我们的结果表明,聚多卡醇经皮硬化疗法治疗 ABC 具有很高的疗效,副作用发生率低。我们的发现与以前发表的文献数据一致。我们认为,该方法在骨盆和骶骨的 ABC 中尤其有价值,因为手术会带来相当大的发病率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/80e7/3822137/ae093aa38999/ORT-84-502-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/80e7/3822137/4332693c097c/ORT-84-502-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/80e7/3822137/ae093aa38999/ORT-84-502-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/80e7/3822137/4332693c097c/ORT-84-502-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/80e7/3822137/ae093aa38999/ORT-84-502-g002.jpg

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Percutaneous radionuclide ablation of axial aneurysmal bone cysts.经皮放射性核素消融治疗轴向骨囊肿动脉瘤。
AJR Am J Roentgenol. 2010 Jan;194(1):W84-90. doi: 10.2214/AJR.09.2568.
3
Is sclerotherapy better than intralesional excision for treating aneurysmal bone cysts?硬化疗法治疗骨囊肿优于病灶内切除吗?
J Clin Orthop Trauma. 2025 Apr 4;66:103009. doi: 10.1016/j.jcot.2025.103009. eCollection 2025 Jul.
4
Qualitative evaluation of magnetic resonance imaging features in aneurysmal bone cysts after percutaneous cryoablation.经皮冷冻消融术后动脉瘤样骨囊肿磁共振成像特征的定性评估
Pediatr Radiol. 2025 May;55(6):1112-1117. doi: 10.1007/s00247-025-06199-1. Epub 2025 Mar 15.
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Minimally Invasive Treatment of Aneurysmal Bone Cysts with Gelified Ethanol (DiscoGel®): Evaluation of Feasibility, Safety, and Efficacy.用凝胶化乙醇(DiscoGel®)微创治疗动脉瘤样骨囊肿:可行性、安全性和有效性评估
Cardiovasc Intervent Radiol. 2025 May;48(5):653-662. doi: 10.1007/s00270-025-03963-6. Epub 2025 Jan 27.
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J Orthop Case Rep. 2024 Oct;14(10):102-106. doi: 10.13107/jocr.2024.v14.i10.4826.
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