Chatziralli Irini P, Jaulim Adil, Peponis Vasileios G, Mitropoulos Panagiotis G, Moschos Marilita M
Department of Ophthalmology, Barts and the London NHS Trust , London , UK .
Semin Ophthalmol. 2014 Mar;29(2):85-107. doi: 10.3109/08820538.2013.833271. Epub 2013 Oct 30.
Retinal vein occlusion is the second most common retinal vascular disorder after diabetic retinopathy and is considered to be an important cause of visual loss. In this review, our purpose is to update the literature about the treatment alternatives for branch retinal vein occlusion.
Eligible papers were identified by a comprehensive literature search of PubMed, using the terms "branch retinal vein occlusion," "therapy," "intervention," "treatment," "vitrectomy," "sheathotomy," "laser," "anti-VEGF," "pegaptanib," "bevacizumab," "ranibizumab," "triamcinolone," "dexamethasone," "corticosteroids," "non-steroids," "diclofenac," "hemodilution," "fibrinolysis," "tPA," and "BRVO." Additional papers were also selected from reference lists of papers identified by the electronic database search.
Treatment modalities were analyzed.
There are several treatment modalities for branch retinal vein occlusion and specifically for its complications, such as macular edema, vitreous hemorrhage, retinal neovascularization, and retinal detachment, including anti-aggregative therapy and fibrinolysis, isovolemic hemodilution, vitrectomy with or without sheathotomy, peripheral scatter and macular grid retinal laser therapy, non-steroid agents, intravitreal steroids, and intravitreal anti-vascular endothelial growth factors (anti-VEGFs).
视网膜静脉阻塞是仅次于糖尿病视网膜病变的第二常见的视网膜血管疾病,被认为是视力丧失的重要原因。在本综述中,我们的目的是更新关于视网膜分支静脉阻塞治疗选择的文献。
通过对PubMed进行全面的文献检索来确定符合条件的论文,检索词包括“视网膜分支静脉阻塞”“治疗”“干预”“疗法”“玻璃体切除术”“鞘膜切开术”“激光”“抗血管内皮生长因子”“培加替尼”“贝伐单抗”“雷珠单抗”“曲安奈德”“地塞米松”“皮质类固醇”“非类固醇”“双氯芬酸”“血液稀释”“纤维蛋白溶解”“组织型纤溶酶原激活剂”和“视网膜分支静脉阻塞”。还从电子数据库搜索确定的论文参考文献列表中选择了其他论文。
对治疗方式进行了分析。
对于视网膜分支静脉阻塞及其并发症,如黄斑水肿、玻璃体积血、视网膜新生血管形成和视网膜脱离,有多种治疗方式,包括抗聚集治疗和纤维蛋白溶解、等容血液稀释、伴或不伴鞘膜切开术的玻璃体切除术、周边视网膜光凝和黄斑格栅视网膜激光治疗、非甾体类药物、玻璃体内注射类固醇以及玻璃体内注射抗血管内皮生长因子。