Department of Ophthalmology, Konyang University College of Medicine, Daejeon, Korea.
Korean J Ophthalmol. 2021 Apr;35(2):159-167. doi: 10.3341/kjo.2020.0143. Epub 2021 Apr 5.
To analyze the repeatability of vessel density (VD) measurements and manual foveal avascular zone (FAZ) measurements using optical coherence tomography angiography (OCTA) in patients with retinal vein occlusion (RVO) without macular edema.
The study population consisted of patients with RVO and central macular thickness <300 μm. For each subject, measurements were performed twice with a 5-minute interval. The intraclass correlation coefficient (ICC) and coefficient of variation (CV) were calculated to analyze the repeatability of results obtained with the OCTA device. To identify factors related to repeatability, we performed Pearson correlation analyses based on the CV of potential factors.
A total of 48 eyes were included in the study. The ICCs of the VDs in superficial capillary plexus (SCP) and the deep capillary plexus (DCP) were 0.748 and 0.665, respectively, and the CVs of the VDs in SCP and DCP were 9.1% and 12.6%, respectively. The ICCs associated with the FAZ of the superficial layer (SFAZ) and that of the deep layer (DFAZ) were 0.965 and 0.956, respectively, and the CV of the SFAZ and DFAZ were 8.8% and 9.7%, respectively. From Pearson correlation analyses, OCTA quality was significantly correlated with the CV of the VDs of SCP and DCP. However, there were no variables that were significantly correlated with the CV of SFAZ and DFAZ, including OCTA quality.
VD measurements in the SCP layer using OCTA exhibited good repeatability, and VD measurements in the DCP layer exhibited relatively low repeatability compared to that of SCP layer measurements in patients with RVO without macular edema after treatment with bevacizumab. Manual measurement of the FAZ area in both SCP and DCP layers resulted in good repeatability. In addition, the repeatability of VD measurements in SCP and DCP layers was correlated with OCTA image quality.
分析无黄斑水肿视网膜静脉阻塞（RVO）患者使用光相干断层扫描血管造影（OCTA）测量血管密度（VD）和手动黄斑中心无血管区（FAZ）的重复性。
研究人群包括 RVO 患者，且中央视网膜厚度＜300μm。每位受试者两次测量之间间隔 5 分钟。使用组内相关系数（ICC）和变异系数（CV）来分析 OCTA 设备测量结果的重复性。为了确定与重复性相关的因素，我们根据潜在因素的 CV 进行 Pearson 相关分析。
本研究共纳入 48 只眼。浅层毛细血管丛（SCP）和深层毛细血管丛（DCP）的 VD 的 ICC 分别为 0.748 和 0.665，SCP 和 DCP 的 VD 的 CV 分别为 9.1%和 12.6%。浅层 FAZ（SFAZ）和深层 FAZ（DFAZ）的 ICC 分别为 0.965 和 0.956，SFAZ 和 DFAZ 的 CV 分别为 8.8%和 9.7%。Pearson 相关分析显示，OCTA 质量与 SCP 和 DCP 的 VD 的 CV 显著相关。然而，没有变量与 SFAZ 和 DFAZ 的 CV 显著相关，包括 OCTA 质量。
在接受贝伐单抗治疗后无黄斑水肿的 RVO 患者中，OCTA 测量 SCP 层的 VD 重复性较好，而 DCP 层的 VD 重复性相对较差。手动测量 SCP 和 DCP 层的 FAZ 面积重复性较好。此外，SCP 和 DCP 层 VD 测量的重复性与 OCTA 图像质量相关。
