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Curr Opin Ophthalmol. 2014 May;25(3):213-20. doi: 10.1097/ICU.0000000000000042.
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Early peripheral laser photocoagulation of nonperfused retina improves vision in patients with central retinal vein occlusion (Results of a proof of concept study).早期非灌注视网膜周边激光光凝治疗改善视网膜中央静脉阻塞患者的视力（概念验证研究结果）。
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Comparison of ultra-widefield fluorescein angiography with the Heidelberg Spectralis(®) noncontact ultra-widefield module versus the Optos(®) Optomap(®).超广角荧光血管造影术：Heidelberg Spectralis（®）非接触超广角模块与Optos（®）Optomap（®）的比较
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Vascular endothelial growth factor promotes progressive retinal nonperfusion in patients with retinal vein occlusion.血管内皮生长因子促进视网膜静脉阻塞患者的视网膜进行性无灌注。
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Peripheral retinal ischaemia, as evaluated by ultra-widefield fluorescein angiography, is associated with diabetic macular oedema.周边视网膜缺血，通过超广角荧光素血管造影评估，与糖尿病黄斑水肿有关。
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Ultra-wide-field angiography improves the detection and classification of diabetic retinopathy.超广角血管造影提高糖尿病视网膜病变的检出率和分类准确率。
Retina. 2012 Apr;32(4):785-91. doi: 10.1097/IAE.0b013e3182278b64.
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Peripheral areas of nonperfusion in treated central retinal vein occlusion as imaged by wide-field fluorescein angiography.经广角荧光素血管造影成像显示，治疗后的中央视网膜静脉阻塞的无灌注周边区。
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视网膜分支静脉阻塞中的周边视网膜无灌注与治疗反应

Peripheral retinal non-perfusion and treatment response in branch retinal vein occlusion.

作者信息

Abri Aghdam Kaveh, Reznicek Lukas, Soltan Sanjari Mostafa, Framme Carsten, Bajor Anna, Klingenstein Annemarie, Kernt Marcus, Seidensticker Florian

机构信息

Department of Ophthalmology, University Eye Hospital, Medical School of Hannover, Carl-Neuberg-Straße 1, Hannover 30625, Germany.

Department of Ophthalmology, Ludwig Maximilians University, Mathildenstr. 8, Munich 80336, Germany.

出版信息

Int J Ophthalmol. 2016 Jun 18;9(6):858-62. doi: 10.18240/ijo.2016.06.12. eCollection 2016.

DOI:10.18240/ijo.2016.06.12
PMID:27366688
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4916143/
Abstract

AIM

To evaluate the association between the size of peripheral retinal non-perfusion and the number of intravitreal ranibizumab injections in patients with treatment-naive branch retinal vein occlusion (BRVO) and macular edema.

METHODS

A total of 53 patients with treatment-naive BRVO and macular edema were included. Each patient underwent a full ophthalmologic examination including optical coherence tomography (OCT) imaging and ultra wide-field fluorescein angiography (UWFA). Monthly intravitreal ranibizumab injections were applied according to the recommendations of the German Ophthalmological Society. Two independent, masked graders quantified the areas of peripheral retinal non-perfusion.

RESULTS

Intravitreal injections improved best-corrected visual acuity (BCVA) significantly from 22.23±16.33 Early Treatment of Diabetic Retinopathy Study (ETDRS) letters to 36.23±15.19 letters (P<0.001), and mean central subfield thickness significantly reduced from 387±115 µm to 321±115 µm (P=0.01). Mean number of intravitreal ranibizumab injections was 3.61±1.56. The size of retinal non-perfusion correlated significantly with the number of intravitreal ranibizumab injections (R=0.724, P<0.001).

CONCLUSION

Peripheral retinal non-perfusion in patients with BRVO associates significantly with intravitreal ranibizumab injections in patients with BRVO and macular edema.

摘要

目的

评估初治视网膜分支静脉阻塞（BRVO）合并黄斑水肿患者周边视网膜无灌注区大小与玻璃体内注射雷珠单抗次数之间的关联。

方法

共纳入53例初治BRVO合并黄斑水肿患者。每位患者均接受了包括光学相干断层扫描（OCT）成像和超广角荧光素血管造影（UWFA）在内的全面眼科检查。根据德国眼科学会的建议进行每月一次的玻璃体内雷珠单抗注射。两名独立的、不知情的分级人员对周边视网膜无灌注区面积进行量化。

结果

玻璃体内注射后，最佳矫正视力（BCVA）从22.23±16.33糖尿病视网膜病变早期治疗研究（ETDRS）视力表字母显著提高至36.23±15.19字母（P<0.001），平均中心子野厚度从387±115 µm显著降低至321±115 µm（P=0.01）。玻璃体内雷珠单抗注射的平均次数为3.61±1.56次。视网膜无灌注区大小与玻璃体内雷珠单抗注射次数显著相关（R=0.724，P<0.001）。

结论

BRVO患者的周边视网膜无灌注与BRVO合并黄斑水肿患者玻璃体内注射雷珠单抗显著相关。