Tardif Suzette D, Coleman Kristine, Hobbs Theodore R, Lutz Corrine
ILAR J. 2013;54(2):234-45. doi: 10.1093/ilar/ilt040.
This article will detail some of the issues that must be considered as institutional animal care and use committees (IACUCs) review the use of nonhuman primates (NHPs) in research. As large, intelligent, social, long-lived, and non-domesticated animals, monkeys are amongst the most challenging species used in biomedical research and the duties of the IACUC in relation to reviewing research use of these species can also be challenging. Issues of specific concern for review of NHP research protocols that are discussed in this article include scientific justification, reuse, social housing requirements, amelioration of distress, surgical procedures, and humane endpoints. Clear institutional policies and procedures as regards NHP in these areas are critical, and the discussion of these issues presented here can serve as a basis for the informed establishment of such policies and procedures.
本文将详细阐述一些在机构动物护理与使用委员会（IACUCs）审查非人类灵长类动物（NHPs）用于研究时必须考虑的问题。作为大型、聪明、群居、长寿且未被驯化的动物，猴子是生物医学研究中最具挑战性的物种之一，IACUC在审查这些物种的研究用途方面的职责也可能具有挑战性。本文讨论的在审查NHP研究方案时特别关注的问题包括科学合理性、重复使用、群居要求、痛苦缓解、外科手术程序以及人道终点。在这些领域，关于NHP的明确机构政策和程序至关重要，此处对这些问题的讨论可作为明智制定此类政策和程序的基础。
