西红花及其成分西红花醛提取物对致敏豚鼠血清内皮素和总蛋白水平的影响。
The Extract of Crocus sativus and Its Constituent Safranal, Affect Serum Levels of Endothelin and Total Protein in Sensitized Guinea Pigs.
机构信息
Applied Physiology Research Centre, and Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
出版信息
Iran J Basic Med Sci. 2013 Sep;16(9):1022-6.
OBJECTIVE(S): The effect of the extract of Crocus sativus and its constituent, safranal on inflammatory markers in sensitized guinea pigs was examined.
MATERIALS AND METHODS
Ovalbumin (OA) sensitized guinea pigs were given drinking water alone (group S), or drinking water containing three concentrations of safranal, three concentrations of extract and one concentration of dexamethasone, (n=6, for all groups) and serum levels of endotheline-1 (ET-1) and total protein (TP) were assessed.
RESULTS
Serum levels of ET-1 and TP in group S were significantly higher than control group (P<0.01 for ET-1 and P<0.001 TP). Treatment of S animals with dexamethasone, most concentrations of the extract and safranal significantly reduced serum levels of ET-1 and TP compared to group S (P <0.01 to P <0.001). The effects of one concentration of the extract and safranal were significantly higher than dexamethasone (P <0.05 to P <0.01).
CONCLUSION
A preventive effect of the extract of C. sativus and its constituent safranal on serum inflammatory markers in sensitized guinea pigs was shown.
目的
研究番红花提取物及其成分西红花醛对致敏豚鼠炎症标志物的影响。
材料和方法
用卵清蛋白（OA）对豚鼠进行致敏，然后给予其饮用水（S 组）或含三种浓度西红花醛、三种浓度提取物和一种浓度地塞米松的饮用水（每组 n=6），并评估血清内皮素-1（ET-1）和总蛋白（TP）水平。
结果
S 组血清 ET-1 和 TP 水平明显高于对照组（ET-1 为 P<0.01，TP 为 P<0.001）。与 S 组相比，用地塞米松、大多数浓度的提取物和西红花醛处理 S 动物可显著降低血清 ET-1 和 TP 水平（P <0.01 至 P <0.001）。一种浓度的提取物和西红花醛的效果明显高于地塞米松（P <0.05 至 P <0.01）。
结论
番红花提取物及其成分西红花醛对致敏豚鼠血清炎症标志物具有预防作用。
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