Boskabady Mohammad Hossein, Jalali Sedigheh, Yahyazadeh Negin, Boskabady Mostafa
Neurogenic Inflammation Research Centre and Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Biology, Payam Noor University, 19395-4697 Tehran, Iran.
Avicenna J Phytomed. 2016 Nov-Dec;6(6):636-642.
Pharmacological effects of carvacrol such as its anti-inflammatory activities have been shows. In this study the effects of carvacrol on serum levels of total protein (TP), phospholipase A2 (PLA2) and histamine in sensitized guinea pigs was evaluated.
Sensitized guinea pigs were given drinking water alone (group S), drinking water containing three concentrations of carvacrol (40, 80 and 160 µg/ml) or dexamethasone. Serum levels of TP, PLA2 and histamine were examined I all sensitized groups as well as a non-sensitized control group (n=6 for each group).
In sensitized animals, serum levels of TP, PLA2 and histamine were significantly increased compared to control animals (p0.05 to p0.001). Significant reduction in TP, PLA2 and histamine levels were observed in treated groups with the two higher concentrations of carvacrol but dexamethasone treatment only decreased serum level of PLA2 (p<0.05 to p0.001). Although the effect of the lowest concentration of the extract was less than that of dexamethasone (p0.05 for TP and p0.001 for PLA2), the effects of the two higher concentrations on PLA2 were similar to dexamethasone and on TP (p0.01) and histamine (p0.001) were higher than those of dexamethasone.
These results showed that carvacrol reduced serum levels of TP, PLA2 and histamine in sensitized guinea pigs which may indicate an anti-inflammatory effect of this agent in inflammatory disorders such as asthma.
香芹酚的药理作用如抗炎活性已得到证实。本研究评估了香芹酚对致敏豚鼠血清总蛋白（TP）、磷脂酶A2（PLA2）和组胺水平的影响。
给致敏豚鼠分别提供单独的饮用水（S组）、含有三种浓度香芹酚（40、80和160μg/ml）的饮用水或地塞米松。检测所有致敏组以及一个未致敏对照组（每组n = 6）的血清TP、PLA2和组胺水平。
与对照动物相比，致敏动物血清中的TP、PLA2和组胺水平显著升高（p<0.05至p<0.001）。在接受两种较高浓度香芹酚治疗的组中，观察到TP、PLA2和组胺水平显著降低，但地塞米松治疗仅降低了血清PLA2水平（p<0.05至p<0.001）。虽然提取物最低浓度的效果低于地塞米松（TP为p>0.05，PLA2为p<0.001），但两种较高浓度对PLA2的作用与地塞米松相似，对TP（p<0.01）和组胺（p<0.001）的作用高于地塞米松。
这些结果表明，香芹酚降低了致敏豚鼠血清中的TP、PLA2和组胺水平，这可能表明该药物在哮喘等炎症性疾病中具有抗炎作用。
