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本文引用的文献

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In vitro infection of human umbilical cord blood CD34+ hematopoietic progenitor cells by HIV-1 CRF07_BC enveloped pseudovirus.
Curr HIV Res. 2012 Oct;10(7):572-7. doi: 10.2174/157016212803305989.
2
Latent HIV-1 infection occurs in multiple subsets of hematopoietic progenitor cells and is reversed by NF-κB activation.潜伏的 HIV-1 感染发生在多个造血祖细胞亚群中，并可通过 NF-κB 激活来逆转。
J Virol. 2012 Sep;86(17):9337-50. doi: 10.1128/JVI.00895-12. Epub 2012 Jun 20.
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Metabolic and cardiovascular complications in HIV-infected patients: new challenges for a new age.HIV感染患者的代谢和心血管并发症：新时代的新挑战。
J Infect Dis. 2012 Jun;205 Suppl 3(Suppl 3):S353-4. doi: 10.1093/infdis/jis202.
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Hematopoietic precursor cells isolated from patients on long-term suppressive HIV therapy did not contain HIV-1 DNA.从长期接受抑制性 HIV 治疗的患者中分离出的造血前体细胞不含 HIV-1 DNA。
J Infect Dis. 2012 Jul 1;206(1):28-34. doi: 10.1093/infdis/jis301. Epub 2012 Apr 25.
5
Circulating interleukin-6 levels correlate with residual HIV viraemia and markers of immune dysfunction in treatment-controlled HIV-infected patients.在治疗得到控制的HIV感染患者中，循环白细胞介素-6水平与残余HIV病毒血症及免疫功能障碍标志物相关。
Antivir Ther. 2012;17(5):915-9. doi: 10.3851/IMP2093. Epub 2012 Mar 21.
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Renal complications in HIV disease: between present and future.HIV 相关肾脏并发症：当下与未来。
AIDS Rev. 2012 Jan-Mar;14(1):37-53.
7
HIV-1 DNA is detected in bone marrow populations containing CD4+ T cells but is not found in purified CD34+ hematopoietic progenitor cells in most patients on antiretroviral therapy.在接受抗逆转录病毒治疗的大多数患者中，骨髓中含有 CD4+ T 细胞的群体可检测到 HIV-1 DNA，但在纯化的 CD34+ 造血祖细胞中未发现 HIV-1 DNA。
J Infect Dis. 2012 Mar 15;205(6):1014-8. doi: 10.1093/infdis/jir884. Epub 2012 Jan 24.
8
Analysis of the effects of HIV-1 Tat on the survival and differentiation of vessel wall-derived mesenchymal stem cells.分析 HIV-1 Tat 对血管壁来源间充质干细胞存活和分化的影响。
J Cell Biochem. 2012 Apr;113(4):1132-41. doi: 10.1002/jcb.23446.
9
HIV-1gp120 induces neuronal apoptosis through enhancement of 4-aminopyridine-senstive outward K+ currents.HIV-1gp120 通过增强 4-氨基吡啶敏感的外向钾电流诱导神经元凋亡。
PLoS One. 2011;6(10):e25994. doi: 10.1371/journal.pone.0025994. Epub 2011 Oct 7.
10
Fine epitope specificity of anti-erythropoietin antibodies reveals molecular mimicry with HIV-1 p17 protein: a pathogenetic mechanism for HIV-1-related anemia.抗促红细胞生成素抗体的精细表位特异性揭示了与 HIV-1 p17 蛋白的分子模拟：HIV-1 相关贫血的发病机制。
J Infect Dis. 2011 Sep 15;204(6):902-11. doi: 10.1093/infdis/jir433.

人类免疫缺陷病毒对红细胞系和巨核细胞系的影响。

Effects of human immunodeficiency virus on the erythrocyte and megakaryocyte lineages.

作者信息

Gibellini Davide, Clò Alberto, Morini Silvia, Miserocchi Anna, Ponti Cristina, Re Maria Carla

机构信息

Davide Gibellini, Alberto Clò, Silvia Morini, Anna Miserocchi, Maria Carla Re, Department of Haematology and Oncological Sciences, Microbiology Section, University of Bologna, 40138 Bologna, Italy.

出版信息

World J Virol. 2013 May 12;2(2):91-101. doi: 10.5501/wjv.v2.i2.91.

DOI:10.5501/wjv.v2.i2.91
PMID:24175233
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3785048/
Abstract

Anaemia and thrombocytopenia are haematological disorders that can be detected in many human immunodeficiency virus (HIV)-positive patients during the development of HIV infection. The progressive decline of erythrocytes and platelets plays an important role both in HIV disease progression and in the clinical and therapeutic management of HIV-positive patients. HIV-dependent impairment of the megakaryocyte and erythrocyte lineages is multifactorial and particularly affects survival, proliferation and differentiation of bone marrow (BM) CD34+ haematopoietic progenitor cells, the activity of BM stromal cells and the regulation of cytokine networks. In this review, we analyse the major HIV-related mechanisms that are involved in the genesis and development of the anaemia and thrombocytopenia observed in HIV positive patients.

摘要

贫血和血小板减少症是血液系统疾病，在许多人类免疫缺陷病毒（HIV）阳性患者的HIV感染过程中都能被检测到。红细胞和血小板的逐渐减少在HIV疾病进展以及HIV阳性患者的临床和治疗管理中都起着重要作用。HIV对巨核细胞和红细胞谱系的损害是多因素的，尤其会影响骨髓（BM）CD34+造血祖细胞的存活、增殖和分化、BM基质细胞的活性以及细胞因子网络的调节。在这篇综述中，我们分析了与HIV阳性患者中观察到的贫血和血小板减少症的发生和发展相关的主要HIV相关机制。