Hsieh Yao-Peng, Huang Ching-Hui, Lee Chia-Ying, Chen Hung-Lin, Lin Ching-Yuang, Chang Chia-Chu
Yao-Peng Hsieh, Chia-Chu Chang, Division of Nephrology, Department of Internal Medicine, Changhua Christian Hospital, Changhua City 500, Taiwan.
World J Nephrol. 2013 May 6;2(2):38-43. doi: 10.5527/wjn.v2.i2.38.
To assess the correlation between the serum hepcidin-25 level and left ventricular mass index.
This study was a cross-sectional study conducted between March 2009 and April 2010. Demographic and biochemical data, including the serum hepcidin-25 level, were collected for chronic kidney disease (CKD) patients. Two-dimensional echocardiography was performed to determine the left ventricle mass (LVM), left ventricular mass index (LVMI), interventricular septum thickness (IVSd), left ventricle posterior wall thickness (LVPW), right ventricular dimension (RVD), left atrium (LA) and ejection fraction (EF).
A total of 146 patients with stage 1 to 5 CKD were enrolled. Serum hepcidin-25 levels were 16.51 ± 5.2, 17.59 ± 5.32, 17.38 ± 6.47, 19.98 ± 4.98 and 22.03 ± 4.8 ng/mL for stage 1 to 5 CKD patients, respectively. Hepcidin-25 level was independently predicted by the serum ferritin level (β = 0.6, P = 0.002) and the estimated glomerular filtration rate (β = -0.48, P = 0.04). There were negative correlations between the serum hepcidin level and the LVM and LVMI (P = 0.04 and P = 0.005, respectively). Systolic blood pressure (BP) was positively correlated with the LVMI (P = 0.005). In the multivariate analysis, a decreased serum hepcidin-25 level was independently associated with a higher LVMI (β = -0.28, 95%CI: -0.48 - -0.02, P = 0.006) after adjusting for body mass index, age and systolic BP.
A lower serum hepcidin level is associated with a higher LVMI in CKD patients. Low hepcidin levels may be independently correlated with unfavorable cardiovascular outcomes in this population.
评估血清铁调素-25水平与左心室质量指数之间的相关性。
本研究为2009年3月至2010年4月期间进行的一项横断面研究。收集慢性肾脏病（CKD）患者的人口统计学和生化数据，包括血清铁调素-25水平。采用二维超声心动图测定左心室质量（LVM）、左心室质量指数（LVMI）、室间隔厚度（IVSd）、左心室后壁厚度（LVPW）、右心室内径（RVD）、左心房（LA）和射血分数（EF）。
共纳入146例1至5期CKD患者。1至5期CKD患者的血清铁调素-25水平分别为16.51±5.2、17.59±5.32、17.38±6.47、19.98±4.98和22.03±4.8 ng/mL。血清铁蛋白水平（β = 0.6，P = 0.002）和估计肾小球滤过率（β = -0.48，P = 0.04）可独立预测铁调素-25水平。血清铁调素水平与LVM和LVMI呈负相关（分别为P = 0.04和P = 0.005）。收缩压（BP）与LVMI呈正相关（P = 0.005）。在多因素分析中，调整体重指数、年龄和收缩压后，血清铁调素-25水平降低与较高的LVMI独立相关（β = -0.28，95%CI：-0.48 - -0.02，P = 0.006）。
CKD患者血清铁调素水平较低与较高的LVMI相关。低铁调素水平可能与该人群不良心血管结局独立相关。
