Falagas M E, Makris G C
Alfa Institute of Biomedical Sciences (AIBS), Athens, Greece.
J Hosp Infect. 2009 Apr;71(4):301-6. doi: 10.1016/j.jhin.2008.12.008. Epub 2009 Feb 6.
The adaptation of strict hygienic practices by healthcare personnel as well as the implementation of appropriate cleaning and disinfection measures form the basis of infection control policies. However, nosocomial infections constitute a considerable problem even in hospitals with meticulous infection control programmes. This should prompt biomedical researchers to evaluate the efficacy and safety of novel infection control measures. There is preliminary evidence that probiotic type micro-organisms may antagonise the growth of nosocomial pathogens on inanimate surfaces. We therefore propose the hypothesis that environmental probiotic organisms may represent a safe and effective intervention for infection control purposes. We suggest that probiotics or their products (biosurfactants), could be applied to patient care equipment, such as tubes or catheters, with the aim of decreasing colonisation of sites by nosocomial pathogens. This could potentially impede a central step in the pathogenesis of nosocomial infections.
医护人员采用严格的卫生措施以及实施适当的清洁和消毒措施是感染控制政策的基础。然而，即使在实施了细致的感染控制计划的医院中，医院感染仍然是一个相当严重的问题。这应该促使生物医学研究人员评估新型感染控制措施的有效性和安全性。有初步证据表明，益生菌类微生物可能会抑制医院病原体在无生命表面的生长。因此，我们提出一个假设，即环境益生菌可能是一种安全有效的感染控制干预措施。我们建议，可以将益生菌或其产品（生物表面活性剂）应用于患者护理设备，如导管或插管，以减少医院病原体在这些部位的定植。这有可能阻碍医院感染发病机制中的一个关键步骤。
